نتایج جستجو برای: numb chin syndrome

تعداد نتایج: 625728  

Journal: :Molecular and cellular biology 1998
T Juven-Gershon O Shifman T Unger A Elkeles Y Haupt M Oren

The Mdm2 oncoprotein is a well-known inhibitor of the p53 tumor suppressor, but it may also possess p53-independent activities. In search of such p53-independent activities, the yeast two-hybrid screen was employed to identify Mdm2-binding proteins. We report that in vitro and in transfected cells, Mdm2 can associate with Numb, a protein involved in the determination of cell fate. This associat...

2013
Tetsufumi Takahashi Hidekazu Suzuki Takao Imai Shinsuke Shibata Yoshiaki Tabuchi Kanji Tsuchimoto Hideyuki Okano Toshifumi Hibi

OBJECTIVE Upregulation of the RNA-binding protein Musashi-1 (Msi1) has been shown to occur in rat gastric corpus mucosa after ethanol-induced mucosal injury. However, there is no direct evidence linking Msi1 with gastric regeneration. We examined the process of tissue repair after acute gastric mucosal injury with Msi1-knock-out (KO) mice to clarify the role of Msi1 and Msi1-dependent regulatio...

خانعلی, سینا, خضریان, لیلا, علیرضایی, پدرام, قاسمی بصیر, حمیدرضا,

Introduction: Parry-Romberg syndrome, a rare syndrome, is characterized by progressive atrophy affecting one side of the face. This disease can include the skin, subcutaneous tissue, muscles, cartilage, and underlying bony structures. Case Presentation: A 27-year-old female was admitted to the outpatient clinic of dermatology of Farshchian Hospital, with chief complaint of asymmetric facial ...

Treacher Collins syndrome (TCS) is a genetic disease that alters the development of bones and other tissues in the face, and presents variable expressivity. At least three genes TCOF1, POLR1D, and POLR1C were recognized to be at the origin of this syndrome which may be inherited through either an autosomal dominant or autosomal recessive pattern. TCS changes can be divided into otological, opht...

2017
Hajime Kikuchi Jun Sakakibara-Konishi Megumi Furuta Hiroshi Yokouchi Hiroshi Nishihara Shigeo Yamazaki Hidetaka Uramoto Fumihiro Tanaka Masao Harada Kenji Akie Fumiko Sugaya Yuka Fujita Kei Takamura Tetsuya Kojima Toshiyuki Harada Mitsunori Higuchi Osamu Honjo Yoshinori Minami Naomi Watanabe Satoshi Oizumi Hiroyuki Suzuki Takashi Ishida Hirotoshi Dosaka-Akita Hiroshi Isobe Mitsuru Munakata Masaharu Nishimura

Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation of small cell lung cancer (SCLC) cell lines. However, in SCLC, the association between Notch1 and Numb expression and clinicopathological factors or pr...

Journal: :The Journal of biological chemistry 2012
Matylda Sczaniecka Karen Gladstone Susanne Pettersson Lorna McLaren Anne-Sophie Huart Maura Wallace

The E3 ubiquitin ligase, MDM2, uses a dual-site mechanism to ubiquitinate and degrade the tumor suppressor protein p53, involving interactions with the N-terminal hydrophobic pocket and the acidic domain of MDM2. The results presented here demonstrate that MDM2 also uses this same dual-site mechanism to bind to the cell fate determinant NUMB with both the N-terminal hydrophobic pocket and the a...

2018
Ivan Nicola Colaluca Andrea Basile Lee Freiburger Veronica D'Uva Davide Disalvatore Manuela Vecchi Stefano Confalonieri Daniela Tosoni Valentina Cecatiello Maria Grazia Malabarba Chun-Jiun Yang Masatsune Kainosho Michael Sattler Marina Mapelli Salvatore Pece Pier Paolo Di Fiore

Numb functions as an oncosuppressor by inhibiting Notch signaling and stabilizing p53. This latter effect depends on the interaction of Numb with Mdm2, the E3 ligase that ubiquitinates p53 and commits it to degradation. In breast cancer (BC), loss of Numb results in a reduction of p53-mediated responses including sensitivity to genotoxic drugs and maintenance of homeostasis in the stem cell com...

Journal: :Development 1995
E P Spana C Kopczynski C S Goodman C Q Doe

The central nervous system (CNS) represents an excellent model system for examining how a multitude of unique cell fates are specified. We find that asymmetric localization of the numb protein autonomously controls a binary cell fate decision in the Drosophila CNS. The simplest lineage in the Drosophila CNS is that of the MP2 precursor: it divides unequally to generate the dMP2 and vMP2 neurons...

Journal: :Mechanisms of Development 2009
Stéphanie Le Bras Géraldine Kriegel-Taki Roland Le Borgne

hypothesis, we used the Cre-loxP system to conditionally inactivate Numb and its homolog Numblike in RPCs at different stages of retinogenesis. We used retroviral vectors expressing Cre recombinase and a reporter to infect Numb/Numblike floxed mouse retinas at early (E13) and late (P0) stages of retinal development. Analysis of cell composition of the resulting knockout clones showed that Numb ...

Journal: :Cell 2008
Frederik Wirtz-Peitz Takashi Nishimura Juergen A. Knoblich

Drosophila neural precursor cells divide asymmetrically by segregating the Numb protein into one of the two daughter cells. Numb is uniformly cortical in interphase but assumes a polarized localization in mitosis. Here, we show that a phosphorylation cascade triggered by the activation of Aurora-A is responsible for the asymmetric localization of Numb in mitosis. Aurora-A phosphorylates Par-6, ...

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