The pathophysiology of Huntington's disease reflects actions of mutant Huntingtin (Htt) (mHtt) protein with polyglutamine repeats, whose N-terminal fragment translocates to the nucleus to elicit neurotoxicity. We establish that the nuclear translocation and associated cytotoxicity of mHtt reflect a ternary complex of mHtt with GAPDH and Siah1, a ubiquitin-E3-ligase. Overexpression of GAPDH or S...

The use of radioactive beams in inverse kinematics dramatically increased the number of isotopes which can be studied at excitation energies ranging from a few to several hundred MeV. Since this method is not subject to target restrictions, long isotopic and isotonic chains could be investigated, and hence, studies of the evolution of fission fragment charge yields, of total kinetic energies, a...

In this talk I discuss properties of hot stellar matter at sub-nuclear densities which is formed in supernova explosions. I emphasize that thermodynamic conditions there are rather similar to those created in the laboratory by intermediate-energy heavy-ion collisions. Theoretical methods developed for the description of multi-fragment final states in such reactions can be used also for descript...

This paper proposes a scheme of using F0 contours of vowel nuclei to discriminate Chinese lexical tones. The authors suggest that the F0 contour fragment of a vowel nucleus of a syllable contributes most to tone perception of the syllable. To correlate the F0 contour with the phonemic components of a syllable, a tone-based syllabic structure is also proposed. Tone recognition experiments on a s...

Suicide attempt linked to breakdown he Golgi apparatus breaks down temporarily to segregate into daughter cells during mitosis, but during apoptosis the organelle fragments irreversibly. On page 637, Chiu et al. report that cleavage of a critical tethering protein during apoptosis not only drives the fragmentation of the Golgi apparatus, but also appears to help propagate the apoptotic signal. ...

Suicide attempt linked to breakdown he Golgi apparatus breaks down temporarily to segregate into daughter cells during mitosis, but during apoptosis the organelle fragments irreversibly. On page 637, Chiu et al. report that cleavage of a critical tethering protein during apoptosis not only drives the fragmentation of the Golgi apparatus, but also appears to help propagate the apoptotic signal. ...

A lzheimer’s disease is a neurodegenerative disorder of the CNS characterized by deposition of neuritic plaques and neurofibrillary tangles with consequent neuron death. Clinically it is characterized by a progressive loss of memory and impairment of learning capacity (Selkoe 1997; Seabrook et al. 1999). Substance P (SP) is a neurotransmitter related to memory functions and learning properties,...

Suicide attempt linked to breakdown he Golgi apparatus breaks down temporarily to segregate into daughter cells during mitosis, but during apoptosis the organelle fragments irreversibly. On page 637, Chiu et al. report that cleavage of a critical tethering protein during apoptosis not only drives the fragmentation of the Golgi apparatus, but also appears to help propagate the apoptotic signal. ...

stats are a family of latent transcription factors that reside in the cytoplasm of resting cells. the stat1 transcription factor gene located on the chromosome 2 at interval 60 to 63 cm. this factor upon stimulation with inf gamma, dimerizes and translocate to the nucleus where mediates transcriptional regulation. in this study, we estimated the allele and genotype frequencies of stat1/pag1 gen...

Mx proteins belong to the dynamin superfamily of high molecular weight GTPases and interfere with multiplication of a wide variety of viruses. Earlier studies show that nuclear mouse Mx1 and human MxA designed to be localized in the nucleus inhibit the transcription step of the in ̄uenza virus genome. Here we set a transient in ̄uenza virus transcription system using luciferase as a reporter gene...