The phosphorus-proton nuclear Overhauser effect (NOE) was used to investigate the quantitative distribution of rotamers about the C3'-03' bond (&') of 3'-AMP and 2',3'-cyclic-CMP and the C4'-C5', C5' 05' bonds (41, 0) of 5'AMP. Phosphorus-proton and proton-proton NOE's were used to provide a qualitative insight into the backbone conformation and the glycosyl angle torsions of adenosylyl-(3' 5')...

Although it appears most probable that coenzyme A is a phosphate derivative of pantothenic acid (2), little information is available as to the position or nature of the phosphate linkage in the molecule. It became of interest in this connection to examine the properties of simple phosphate derivatives of pantothenic acid, and for this purpose efforts were directed toward the preparation of the ...

Formation of mixed-ligand Pd2+ complexes between canonical nucleoside 5'-monophosphates and five metal-ion-binding nucleoside analogs has been studied by 1H-NMR spectroscopy to test the ability of these nucleoside surrogates to discriminate between unmodified nucleobases by Pd2+-mediated base pairing. The nucleoside analogs studied included 2,6-bis(3,5-dimethylpyrazol-1-yl)-, 2,6-bis(1-methylhy...