investigation of aluminium uptake by human erythrocytes was the major aim of this study. packed red blood cells were incubated in earle's medium (ph 7.4) containing varying concentrations of aluminium (0-160 /lg/j) as aik(so.), and aluminium content of the cells were determined using flameless atomic absorption. there was significant increase in aluminium content of the cells. addition of ...

INTRODUCTION In critically ill patients, the appearance of nucleated red blood cells (NRBCs) in blood is associated with a variety of severe diseases. Generally, when NRBCs are detected in the patients' blood, the prognosis is poor. METHODS In a prospective study, the detection of NRBCs was used for a daily monitoring of 383 medical intensive care patients. RESULTS The incidence of NRBCs in...

The effects of cell concentration during cryopreservation on bone marrow (BM) or peripheral blood (PB)-derived hematopoietic progenitor cells have not been described. The much greater numbers of cells harvested for autologous PB stem cell (PBSC) transplantation requires that the cells be frozen at higher cell concentrations, or in much greater volumes, compared with BM. We cryopreserved 108 PBS...

The umbilical cord blood (UCB) is a rich source of hematopoietic and mesenchymal stem cells and it can be used for cellular therapy. This article presents data achieved from 50 cord blood samples (46 in utero, four ex utero). The nucleated cells were isolated from the cord blood using a dextran solution. The quantity of stem cells having the immunophenotype CD34+, CD45+ and CD90+ was determined...

SIFD describes a heritable, syndromic condition characterised principally by sideroblastic anaemia (SA) with immunodeficiency, fevers and developmental delay, arising in mutations within the TRNT1 gene. Other clinical manifestations of SIFD include cardiomyopathy, seizures, sensorineural hearing loss, renal dysfunction, metabolic abnormalities, hepatosplenomegaly and retinitis pigmentosa.Presen...

D URING NORMAL MURINE embryogenesis, erythropoiesis first occurs in the yolk sac blood islands, beginning on days 7-8 of gestation.’ These nucleated erythrocytes primarily synthesize embryonic hemoglobins El (x2y2), Eli (a2y2), and Elil (a2z,).2 5 By day I I of gestation, the fetal liven becomes the major site of red blood cell production, which persists until near birth.6 It has been generally...