We identify Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) as a novel component of neuronal synapses whose absence increases dendritic spine size and filamentous actin levels in an N-WASP/Arp2/3-independent, RhoA/ROCK/profilinIIa-dependent manner. These effects depend on the reduction of membrane sphingomyelin (SM) due to transcriptional upregulation of neutral sphingomyelina...

Abstract The behavior of eccentrically loaded RC columns strengthened by NSM steel and glass fiber reinforced polymer (GFRP) rebars is investigated in this study. A total six column specimens have been cast study with dimensions (150×150×1200) mm (width × height length). Two are unstrengthened considered as controls, while the other method using bars hybrid GFRP rebars. All tested under concent...

Fiber-reinforced polymers (FRPs) have been widely utilized to improve the seismic performance of deficient reinforced concrete (RC) columns. In recent years, one of the emerging types of FRPs used is basalt fibers. In this study, the performance of existing columns was experimentally examined before and after applying near-surface mounted (NSM) basalt FRP (BFRP) rebars as a retrofitting techniq...

BACKGROUND AND PURPOSE The Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) established guidelines to increase safety in acute stroke thrombolysis, but precluding treatment in an important proportion of patients. We aimed to assess safety/efficacy of thrombolysis in patients with SITS-MOST exclusion criteria. METHODS 369 nonlacunar tPA-treated patients were studied. ...

In sea urchin embryos Delta signaling specifies non-skeletogenic mesoderm (NSM). Despite the identification of some direct targets, several aspects of Delta Notch (D/N) signaling remain supported only by circumstantial evidence. To obtain a detailed and more complete image of Delta function we followed a systems biology approach and evaluated the effects of D/N perturbation on expression levels...

We wanted to determine whether the production of endogenous nitric oxide (NO) is affected by cigarette smoking and various pathological conditions. Endogenously produced NO was measured by chemiluminescence in the exhaled air of 81 healthy volunteers (21 nonsmoking females (NSF), 12 smoking females (SF), 24 nonsmoking males (NSM) and 24 smoking males (SM)) and 38 patients (10 with hypertension,...

We propose an adaptive hybrid method suitable for stochastic simulation of diffusion dominated reaction-diffusion processes. For such systems, simulation of the diffusion requires the predominant part of the computing time. In order to reduce the computational work, the diffusion in parts of the domain is treated macroscopically, in other parts with the tau-leap method and in the remaining part...

In this work, the determination of a group of triazolopyrimidine sulfoanilide herbicides (cloransulam-methyl, metosulam, flumetsulam, florasulam, and diclosulam) in soy milk by capillary electrophoresis-mass spectrometry (CE-MS) is presented. The main electrospray interface (ESI) parameters (nebulizer pressure, dry gas flow rate, dry gas temperature, and composition of the sheath liquid) are op...