BACKGROUND This study determined the frequency of drug-related pneumonitis during mammalian target of rapamycin (mTOR) inhibitor therapy in Waldenström macroglobulinemia patients and investigated the imaging characteristics and radiographic patterns of pneumonitis. MATERIALS AND METHODS A total of 40 patients (23 men, 17 women; 43-84 years old) with Waldenström macroglobulinemia treated in 2 ...

(Intern Med 50: 173-174, 2011) (DOI: 10.2169/internalmedicine.50.4363) To the Editor We read with great interest the papers by Tomii and colleagues and Yokoyama and colleagues concerning the use of non-invasive ventilation (NIV) in managing life-threatening acute exacerbation of idiopathic interstitial pneumonia (1, 2). We recently reviewed the data of 30 patients suffering of idiopathic pulmon...

BACKGROUND Traditionally, chronic idiopathic interstitial pneumonia/fibrosis (IIP/F) had included usual interstitial pneumonia, desquamative interstitial pneumonia, and nonspecific interstitial pneumonia (NSIP). More recent classifications have included bronchiolitis obliterans-organizing pneumonia (BOOP), respiratory bronchiolitis-associated interstitial lung disease, and acute interstitial pn...

printing supported by . Visit Chiesi at Stand B2.10 TUESDAY, SEPTEMBER 4TH 2012 P3652 The efficacy of pirfenidone in scleroderma related interstitial lung disease Yukiko Miura1, Yoshiya Tsunoda1, Toru Tanaka1, Hiroyuki Takoi1, Yohei Yatagai1, Shigen Rin1, Akimasa Sekine1, Kenji Hayashihara1, Takefumi Saito1, Akihiko Gemma2, Arata Azuma2. 1Department of Respiratory Medicine, National Hospital Or...

Interstitial lung disease (ILD) induces overwhelming morbidity and kills more patients with connective tissue disease (CTD) than any other CTD-related manifestation. Because of this, there is a keen and growing interest in the rheumatology and pulmonary communities to identify prognostic variables for CTDassociated ILD (CTD-ILD). Treatment options for patients with ILD, idiopathic as well as th...

BACKGROUND Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and limited responsiveness to available treatments. It is characterised by epithelial cell injury, fibroblast activation and proliferation and extracellular matrix deposition. Serotonin (5-hydroxytryptamine; 5-HT) induces fibroblast proliferation via the 5-HTR(2A) and 5-HTR(2B) receptors, but its pathophysiological role in IPF ...

BACKGROUND It is difficult to predict survival in patients with idiopathic pulmonary fibrosis. Recently, several proteins, such as surfactant protein (SP) and KL-6, have been reported to be useful biologic markers for prediction of prognosis for interstitial pneumonias. It is not clear whether there is any relationship between expression of these proteins in regenerative/hyperplastic alveolar e...

Abstract Genetic selection of sheep for resistance to gastrointestinal nematodes (GIN) has become a priority pasture-based production lambs minimize the need deworming. The first objective this experiment was determine impact sire weaning or post-weaning fecal egg count (FEC) estimated breeding value (EBV; WFEC and PFEC, respectively) from National Sheep Improvement Program (NSIP) on GIN infect...