نتایج جستجو برای: ns3 helicase
تعداد نتایج: 10524 فیلتر نتایج به سال:
A Novel Benzoxazole Inhibitor of Dengue Virus Replication that 1 Targets the NS3 Helicase 2 3 Chelsea M. Byrd*, Douglas W. Grosenbach, Aklile Berhanu, Dongcheng Dai, 4 Kevin F. Jones, Kara B. Cardwell, Christine Schneider,Guang Yang, 5 Shanthakumar Tyavanagimatt, Chris Harver, Kristin A. Wineinger, Jessica Page, 6 Eric Stavale, Melialani A. Stone, Kathleen P. Fuller, Candace Lovejoy, 7 Janet M....
A virtual screening analysis of our library of phytochemical structures with dengue virus protein targets has been carried out using a molecular docking approach. A total of 2194 plant-derived secondary metabolites have been docked. This molecule set comprised of 290 alkaloids (68 indole alkaloids, 153 isoquinoline alkaloids, 5 quinoline alkaloids, 13 piperidine alkaloids, 14 steroidal alkaloid...
Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood. Here, we evaluate this concept for hepatitis C virus (HCV), an important cause of chronic liver disease and member of the Flaviviridae family. HCV encodes five nonstructural (NS) g...
BACKGROUND Subtype-specific response to ketoamide NS3 protease inhibitors is observed in patients with genotype 1 HCV infection. Whether the genetic diversity in the molecular target site of ketoamide compounds prior to treatment plays a role for resistance development and lower treatment response in subtype 1a is poorly understood. METHODS Using a public database, we retrieved worldwide NS3-...
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