نتایج جستجو برای: novel anticancer agent

تعداد نتایج: 1047481  

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2002
Xiangming Guan Brianna N Hoffman Douglas C McFarland Kysa K Gilkerson Chandradhar Dwivedi Angela K Erickson Scott Bebensee Jill Pellegrini

Sulofenur is one of the diarylsulfonylureas developed as an anticancer agent. Sulofenur possesses a broad spectrum of activity in several solid tumor models and has undergone extensive clinical trials based on its impressive preclinical activity. However, the clinical response of sulofenur has been disappointing because of the side effect of anemia. Furthermore, the anticancer mechanism of sulo...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2006
S Faivre E Raymond

editorial Management of neuromuscular dose limiting toxicity at the early stage of drug development Non-hematological toxicities, including neuromuscular toxicity, occurring during phase I trials may prevent novel compounds from undergoing further drug development. Toxicity may also result in the recommendation of low doses and inappropriate schedules with no antitumor activity, rapidly reducin...

Journal: :Asian Journal of Natural Product Biochemistry 2021

Abstract. Bailly C. 2021. Anticancer mechanism of artonin E and related prenylated flavonoids from the medicinal plant Artocarpus elasticus. Asian J Nat Prod Biochem 19: 44-56. Plants genus are largely distributed throughout tropical Asia Oceania. Species such as A. altilis (Parkinson) Fosberg heterophyllus Lam. popular trees known breadfruit jackfruit, respectively. They contain a large struct...

Journal: :Oncology reports 2016
Minyong Kang Jin-Nyoung Ho Ha Rim Kook Sangchul Lee Jong Jin Oh Sung Kyu Hong Sang Eun Lee Seok-Soo Byun

In the present study, we aimed to investigate the anticancer properties of Theracurmin®, a novel form of the yellow curry pigment curcumin, as well as explore the molecular mechanisms of the potential anticancer effects of Theracurmin® on human prostate cancer and bladder cancer cells in vitro. The proliferation of cancer cells was examined by using the Cell Counting Kit-8. The clonogenic growt...

Journal: :Organic & Medicinal Chemistry International Journal 2019

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