Background: The ratio of urine protein to urine osmolality has recently been suggested as an accurate method to determine proteinuria.  Objective: We studied the correlation of urine protein to urine osmolality ratio with 24-hr urinary protein excretion. Methods: 150 children aged 0.11–17 years admitted to the Department of Pediatric Nephrology were included in this study. Early morning urine s...

Chronic inflammation contributes to the development and progression of chronic kidney disease (CKD). Identifying renal inflammation early is important. There are currently no specific markers of renal inflammation. Endothelin-1 (ET-1) is implicated in the pathogenesis of CKD. Thus, we investigated the impact of progressive renal dysfunction and renal inflammation on plasma and urinary ET-1 conc...

Pathogenetic studies have demonstrated that the interdependency of sodium and potassium affects blood pressure. Emerging evidences on the sodium-to-potassium ratio show benefits for a reduction in sodium and an increase in potassium compared to sodium and potassium separately. As presently there is no known review, this article examined the practical use of the sodium-to-potassium ratio in dail...

background: the ratio of urine protein to urine osmolality has recently been suggested as an accurate method to determine proteinuria.   objective: we studied the correlation of urine protein to urine osmolality ratio with 24-hr urinary protein excretion.   methods: 150 children aged 0.11–17 years admitted to the department of pediatric nephrology were included in this study. early morning urin...

Abstract Background and Aims Hypertension is frequently associated with hypercalciuria1, nephrolithiasis2 low bone mineral density. Familial Hyperkalaemic (FHHt) causes hypercalciuria3, although complications of this are not reported. Method We examined a cohort 9 patients genetically confirmed FHHt. Biochemical, radiological, clinical data was obtained in before after thiazide treatment. All g...

BACKGROUND Urine is increasingly becoming an attractive biological fluid in clinical practice due to being an easily obtained, non-invasive sampling method, containing proteins and peptides. The aim of this study was to investigate eosinophiluria, urinary eosinophil cationic protein (uECP) and urinary IL-5 (uIL-5) in patients with Lupus Nephritis. METHODS Seventy-four patients with SLE-20 wit...

Background. Despite enzyme replacement therapy, Fabry nephropathy still progresses. Podocyturia is an irreversible event that antedates proteinuria and leads to chronic renal failure. We evaluated a potential mechanism of podocyte detachment via the expression of the urokinase-type Plasminogen Activator Receptor (uPAR) in urinary podocytes of Fabry patients. Methods. This is a cross-sectional s...

Abstract Background and Aims Low sodium intake is associated with a lower blood pressure less proteinuria, which are important therapeutic targets in chronic kidney disease. In contrast, low potassium has been higher incidence of disease cardiovascular events. Counselling patients regarding their requires accurate estimation intake, but 24-hour urinary excretion can deviate substantially from a...

To determine whether the sympathetic nervous system contributes to the hypertension induced by pathophysiological increments in plasma angiotensin II (Ang II) concentration, we determined the neurally induced changes in renal excretory function during chronic intravenous infusion of Ang II. Studies were carried out in five conscious chronically instrumented dogs subjected to unilateral renal de...

of this pilot study was to estimate the salt intake of Moroccan adults by measuring 24-hour urinary sodium excretion. Methods: 132 participants were recruited from the central region of Morocco. Sodium, potassium and creatinine levels were measured using the 24-hour urine samples. Additional data included anthropometric measurements and socio-demographic questionnaire. Results: The daily sodium...