Introduction: In 3DCRT the number of therapeutic fields has dramatic impact on treatment results especially in stomach cancer. Traditionally, for radiotherapy of stomach cancer the therapeutic procedure was using two fields (AP- PA or AP Lateral with wedge) to achieve smooth and homogeneous dose distribution in tumor. But nowadays, adding lateral or oblique fields to aforement...

To obtain a favorable tradeoff between treatment benefits and morbidity ("therapeutic ratio"), radiotherapy (RT) dose is prescribed according to the tumor volume, with the goal of controlling the disease while respecting normal tissue tolerance levels. We propose a new paradigm for tumor dose prescription in stereotactic ablative radiotherapy (SABR) based on organ-at-risk (OAR) tolerance levels...

Radiotherapy treatment outcome models are a complicated function of treatment, clinical and biological factors. Our objective is to provide clinicians and scientists with an accurate, flexible and user-friendly software tool to explore radiotherapy outcomes data and build statistical tumour control or normal tissue complications models. The software tool, called the dose response explorer syste...

Introduction: Radiobiological modeling of radiotherapy plans are used for treatment plan comparisons. The current study aimed to compare the three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) plans for nasopharyngeal cancer using radiobiological modeling. Materials and Methods: This study was conducted on 10 patients with nasopharyngeal carci...

Background: The dose-related effects of patient setup errors on bio-physical indices were evaluated for the conventional wedge (CW) and field-in-field (FIF) whole breast irradiation techniques (WBI). Materials and Methods: The treatment plans of 10 patients receiving left WBI were retrospectively selected for evaluation. The bio-physical effects of dose variations were evaluated by shifting the...

The radiation killing of tumor cells by ionizing radiation is best described by the linear-quadratic (LQ) model. Research into the underlying mechanisms of α- and β-inactivation has suggested that different molecular targets (DNA in different forms) and different microdosimetric energy deposits (spurs versus electron track-ends) are involved. Clinical protocols with fractionated doses of about ...

Thrombotic thrombocytopenic purpura (TTP) is a rare complication of connective tissue diseases. Here, we describe 2 patients with mixed connective tissue disease (MCTD) who had pericardial effusion and TTP. They had moderately low to normal ADAMTS13 activity and no ADAMTS13 neutralizing antibodies. Both patients responded poorly to plasma exchange. One patient died due to multiple organ failure...