This study investigates the mechanics of normal pressure hydrocephalus (NPH) growth using a computational approach. We created a generic 3-D brain mesh of a healthy human brain and modelled the brain parenchyma as single phase and biphasic continuum. In our model, hyperelastic constitutive law and finite deformation theory described deformations within the brain parenchyma. We used a value of 1...

Normal pressure hydrocephalus is a devious phenomenon. It is a disease that is difficult to diagnose and difficult to treat, the only treatment being a ventriculo-peritoneal shunt, though good shunting results rarely pass a 70% level of effectiveness. We need to understand its pathophysiology better before things will improve. Although some colleagues know it as a possible “reversible dementia”...

BACKGROUND AND PURPOSE Normal pressure hydrocephalus (NPH) is considered to be a combination of altered CSF resorption and a reversible form of cerebral ischemia. The hypothesis tested in this study was that a reduction in venous compliance in the territory drained by the superior sagittal sinus (SSS) is associated with NPH and cerebral ischemia. METHODS This prospective study involved 27 pat...

OBJECTIVE Determination of jugular venous pressure (JVP) by physical examination (E-JVP) is unreliable. Measurement of JVP with ultrasonography (U-JVP) is easy to perform, but the normal range is unknown. The objective of this study was to determine the normal range for U-JVP. METHODS We conducted a prospective anatomic study on a convenience sample of emergency department (ED) patients over ...

BACKGROUND Since the condition was first described in 1965, the syndrome of normal pressure hydrocephalus (NPH) has conventionally been managed by placement of a cerebrospinal fluid (CSF) shunt. OBJECTIVES To determine the effectiveness of shunting procedures in promoting stability or improvement in the neurological symptoms and signs of NPH. SEARCH STRATEGY The trials were identified from ...

Introduction Normal pressure hydrocephalus (NPH) is a clinical syndrome characterized by enlargement of the brain’s ventricular spaces without obstruction of cerebrospinal fluid (CSF) flow or elevation in CSF pressure. This condition may develop from a variety of processes that cause decreased resorbtion or over-production of CSF. The net effect of NPH is a reduction in the compliance of the br...

background: with respect to physical relations in force and pressure, we hypothesized that the prevalence of traumatic tympanic membrane perforation in patients with a patulous eustachian tube is greater than normal, because in eustachian tube patency, the internal air pressure of the middle ear will not increase after compression, subsequent to trauma. therefore the force upon the tympanic mem...

Seventeen of 33 patients (51.5%) with normal pressure hydrocephalus were discovered to have diabetes mellitus. This was significantly greater than the 12.1% incidence found in age-matched control subjects. The diabetes was not accounted for either by the patients' ages nor by their physical inactivity due to hospitalisation. Diabetes mellitus concurrent with normal pressure hydrocephalus may re...

A xenon-133 method was used to measure cerebral blood flow (CBF) before and after cerebrospinal fluid (CSF) removal in patients with normal pressure hydrocephalus (NPH). Preliminary results suggested that shunting should be performed on patients whose CBF increased after CSF removal. There was a significant increase in CBF in patients with NPH, which was confirmed by the favorable outcome of 88...