نتایج جستجو برای: nonsmall cell lung cancer nsclc
تعداد نتایج: 2482650 فیلتر نتایج به سال:
(18)F-fluoro-2-deoxy-d-glucose positron emission tomography (PET) complements conventional imaging for diagnosing and staging lung cancer. Two literature-based meta-analyses suggest that maximum standardised uptake value (SUVmax) on PET has univariate prognostic value in nonsmall cell lung cancer (NSCLC). We analysed individual data pooled from 12 studies to assess the independent prognostic va...
Distinguishing nonsmall cell lung cancer (NSCLC) from small cell lung cancer (SCLC) is of paramount importance, since the treatment and prognosis of the cancers are often significantly different. SCLC is well known to exhibit massive lymphadenopathy, direct mediastinal invasion and paraneoplastic syndromes [1]. However, there is considerable clinical overlap between NSCLC and SCLC such that cli...
Angiopoietin-2 (Ang2) is a key proangiogenic factor, but its role in surgery-induced angiogenesis, a possible cause of cancer recurrence, is still elusive.We measured the plasma Ang2 levels in healthy controls (n = 42) and stage I-IV perioperative nonsmall cell lung cancer (NSCLC) patients (n = 227) with enzyme-linked immunosorbent assay, and examined the impact of Ang2 in the plasmas on in vit...
AIM The aim of the study was to validate the expression of protein tyrosine kinase 6 (PTK6) in nonsmall cell lung cancer (NSCLC), and to evaluate its clinicopathological and prognostic significance. METHODS We first conducted a meta-analysis on the mRNA profiling data sets of NSCLC in the Oncomine database. Then, one of the most significantly upregulated tyrosine kinase targets, PTK6, was fur...
Objective(s): Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (NSCLC) exhibit TRAIL-resistance. The purpose of this study was to determine whether subtoxic-dose cisplatin and TRAIL could synergistically enhance apoptosis on NSCLC cells and investigate its under...
PURPOSE Statins are known to have pleiotropic effects that induce cell death in certain cancer cells. BIM is a member of the bcl-2 gene family, which promotes apoptotic cell death. This study investigated the hypothesis that simvastatin has pro-apoptotic effects in epidermal growth factor receptor (EGFR)-mutated lung cancer cell lines via the upregulation of the expression of the BIM protein. ...
BACKGROUND/AIM For the early stage of nonsmall-cell lung cancer, surgical resection provides the best survival, but the surgical risk generally increases with age because of the increased prevalence of comorbidities, especially cardiovascular disorders. The aim of this study was to compare survival and mortality rates of two groups with different ages, younger and older than 70 years, who went ...
Summary This year’s virtual version of the European Society for Medical Oncology (ESMO) presidential sessions included three “late breaking” non-small cell lung cancer (NSCLC) abstracts, discussing strategies adjuvant therapy localized disease and up-front treatment advanced anaplastic lymphoma kinase(ALK)-positive cancer.
Cancer of the lung is the leading cause of cancer death in both women and men in the United States. In the year 2012, the estimate is for 226,160 new cases of lung cancer in the US, and 164,770 deaths; the five-year survival rate for lung cancer is 16%. This sobering outlook is due primarily to the fact that most patients have advanced disease at the time of presentation. Nonsmall cell lung can...
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