BACKGROUND An aberrant right subclavian artery (ARSA) with an associated nonrecurrent right inferior laryngeal nerve (NRILN) is a relatively rare anomaly that occurs at a frequency of 0.3 to 2.0% of the general population. NRILN has been mainly documented in the head and neck region; it has been rarely described in patients with esophageal cancer, especially those undergoing thoracoscopic surge...

PURPOSE Epigenetic regulation by promoter methylation plays a key role in tumorigenesis. Our goal was to investigate whether altered DNA methylation signatures associated with oncogenic signaling delineate biomarkers predictive of endometrial cancer recurrence. EXPERIMENTAL DESIGN Methyl-CpG-capture sequencing was used for global screening of aberrant DNA methylation in our endometrial cancer...

A 31-year-old female heart transplant recipient was admitted to the hospital for a recent history of progressively worsening headaches. Her past medical history included doxorubicin (Adriamycin)-induced cardiomyopathy and cisplatin-induced nephropathy secondary to a nonrecurrent osteosarcoma that occurred in 1982; in 1991, she underwent orthotopic heart transplantation. After transplantation (a...

Dietary N-(4-hydroxyphenyl)retinamide (4-HPR; 3 mmol/kg diet) and s.c. injections of the antiestrogen, tamoxifen (Tx; 10 micrograms or 20 micrograms per rat, thrice weekly) were used together as adjunct chemopreventive therapy in groups of 39-40 female, Sprague-Dawley rats that each received an i.v. injection (50 mg/kg b.w.) of the mammary gland carcinogen N-methyl-N-nitrosourea (MNU). Treatmen...

Osteosarcomas are copy number alteration (CNA)-rich malignant bone tumors. Using microarrays, fluorescence in situ hybridization, and quantitative PCR, we characterize a focal region of chr3q13.31 (osteo3q13.31) harboring CNAs in 80% of osteosarcomas. As such, osteo3q13.31 is the most altered region in osteosarcoma and contests the view that CNAs in osteosarcoma are nonrecurrent. Most (67%) ost...

The gene genealogy is derived for a rare allele that is descended from a mutant ancestor that arose at a fixed time in the past. Following Thompson (1976, Amer. J. Human Genet. 28, 442-452), the fractional linear branching process is used as a model of the demography of a rare allele. The model does not require the total population size to be constant or the mutant class to be neutral; so long ...

Rearrangements of our genome can be responsible for inherited as well as sporadic traits. The analyses of chromosome breakpoints in the proximal short arm of Chromosome 17 (17p) reveal nonallelic homologous recombination (NAHR) as a major mechanism for recurrent rearrangements whereas nonhomologous end-joining (NHEJ) can be responsible for many of the nonrecurrent rearrangements. Genome archite...

OBJECTIVES To compare a rapid, cross-sectional frozen-section technique with Mohs micrographic surgery, using recurrence rate and cost of treatment for excision of basal cell carcinoma as indicators to validate our indications for Mohs surgery. DESIGN Retrospective study of 557 head and neck basal cell carcinomas excised over 10 years. MAIN OUTCOME MEASURES Recurrence rates; tumor compariso...

BACKGROUND Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear. METHODS The PTC patients who scheduled to undergo total thyroidectomy by the same surgical team ...

A 31-year-old female heart transplant recipient was admitted to the hospital for a recent history of progressively worsening headaches. Her past medical history included doxorubicin (Adriamycin)-induced cardiomyopathy and cisplatin-induced nephropathy secondary to a nonrecurrent osteosarcoma that occurred in 1982; in 1991, she underwent orthotopic heart transplantation. After transplantation (a...