The vaginal mucosa is a common site for local and systemic delivery of medication. This study aims to compare the safety and toxicological profile of RheoSpray, a proprietary sprayable topical gel compounding base, to the profile of the positive control Gynoll II, using a 3D model of the human vaginal mucosa. Results have demonstrated that RheoSpray presented an ET50 superior to 24 hr, as oppos...

VACCINES “Translating uncertain data into policy is always a difficult issue” is how Gary Nabel, director of the Vaccine Research Center at the NIH, succinctly characterized the new issues complicating the design of AIDS vaccine candidates.1 Concerns arose following not only failure of the latest product but also its association with an increased risk of HIV acquisition. The STEP study (also kn...

For the last 40 y, substantial evidence has surfaced on the hormone-like effects of environmental chemicals such as pesticides and industrial chemicals in wildlife and humans. The endocrine and reproductive effects of these chemicals are believed to be due to their ability to: (1) mimic the effect of endogenous hormones, (2) antagonize the effect of endogenous hormones, (3) disrupt the synthesi...

The purpose of this study was to determine whether 4-chlorom-cresol (4-CmC) could generate caffeine-like responses in ferret cardiac muscle. The concentration dependence of 4-CmC-mediated release of Ca from the sarcoplasmic reticulum was studied in intact cardiac trabeculae and saponinskinned fibers in which the sarcoplasmic reticulum was loaded with Ca. In intact and saponin-skinned preparatio...