Deciphering how Listeria monocytogenes exploits the host cell machinery to invade mammalian cells is a key issue in understanding the pathogenesis of this food-borne pathogen, which can cause diseases ranging from gastroenteritis to meningitis and abortion. In this study, we show that the lysosomal aspartyl-protease cathepsin-D (Ctsd) is of considerable importance for nonoxidative listericidal ...

Most studies of antibody-dependent cellular cytotoxicity (ADCC) by polymorphonuclear leukocytes (PMN) have supported oxidative lytic processes. This may be because the studies used nonhuman or nonneoplastic cells that were highly sensitive to reactive oxygen species or were small enough to be phagocytosed by PMN. We therefore investigated whether oxygen radicals participate in PMN cytotoxicity ...

We present a single-tracer method for the study of the pentose phosphate pathway (PPP) using [1,2-13C2]glucose and mass isotopomer analysis. The metabolism of [1,2-13C2]glucose by the glucose-6-phosphate dehydrogenase, transketolase (TK), and transaldolase (TA) reactions results in unique pentose and lactate isotopomers with either one or two13C substitutions. The distribution of these isotopom...

A high-loading Ga-exchanged MFI zeolite was developed for efficient ethane dehydrogenation. Its high catalytic performance is ascribed to both the low amount of Brønsted acid sites and major formation [GaH 2 ] + ions among isolated Ga hydrides.

Employing extensive co-conversion data for selected and unselected sites of known molecular location in the rosy locus of Drosophila. we determine the parameters of meiotic gene conversion tract length distribution. The tract length distribution for gene conversion events can be approximated by the equation P(L > or = n) = phi n where P is the probability that tract length (L) is greater than o...

le missionnaire est un voyageur particulier qui voyage pour un motif sublime: celui de la propagande du christianisme. les missionnaires ne sont pas très nombreux, mais, ils ont écrit bien de livres par lesquels nous pouvons tracer leur démarche à travers l’asie et la perse en particulier. cet article est consacré à l’étude et l’analyse de cette mission tout d’abord en asie et plus particulière...

in order to gain a better understanding of the chemistry of methanl-to-hydro-carbon conversion, it is necessary to determine the nature of the primary reaction products. experiments carried out in this work on h-zsm-11, using a continuous flow reactor linked to an on-line gas chromatograph demonstrated that ethylene and methane are the primary reaction products. the results obtained using solid...

agricultural land conversion (alc) has been introduced as one of the most important factorsaffecting ecosystem. this type of conversion has led to several challenges in agricultural development andhuman life. monitoring alc plays a crucial role when dealing with such challenges. the main objective of thisstudywas to monitor the trend ofalc in theqazvin province located in northwest iran from 19...