OBJECTIVE This study evaluated the anti-ulcer properties of Croton zambesicus leaves. MATERIALS AND METHODS Group I was control. 40 mg/kg/bodyweight of indomethacin (the ulcerogen) was administered to rats of Groups II-VII. 4 h after administrations of ulcerogen; rats of Groups III-VII were treated daily with oral administrations of 40 mg/kg/bodyweight of omeprazole, 5 and 10 mg/kg/bodyweight...

Meloxicam is a non-steroidal antiinflammatory drug from the subgroup of enolic acid oxicams. Meloxicam is a novel NSAID that has effectively replaced the old pain killers particularly diclofenac sodium which has high toxicity. Meloxicam has a high intrinsic activity combined with a low ulcerogenic potential (i.e. a high therapeutic index) (Engelhardt et al., 1996).Meloxicam is considered as sta...

We examined the influence of adrenalectomy on NSAID-induced small intestinal damage in rats and investigated the possible involvement of adrenal glucocorticoids in the protective effects of urocortin I, a corticotropin-releasing factor (CRF) agonist. Male SD rats without fasting were administered indomethacin s.c. and killed 24 h later in order to examine the hemorrhagic lesions that developed ...

Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastrointestinal ulceration as the adverse reaction. This effect of NSAIDs is attributable to endogenous prostaglandin (PG) deficiency caused by inhibition of cyclooxygenase (COX), yet the relation between COX inhibition and the gastrointestinal ulcerogenic property of NSAIDs remains controversial. Using selective COX inhibitors, we examined ...

and commentary also appear in ACP Journal Club. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr F K Chan, Chinese University of Hong Kong, Shatin, Hong Kong, China. [email protected] Source of funding: no external funding. Clopidogrel v aspirin plus esomeprazole for patients with previous aspirin ...