Vitamin D (VD) is a secosteroid hormone that is mainly synthesized in the skin upon exposure to UVB radiation. VD is widely known for its role in calcium metabolism; however, multiple endocrine, paracrine and autocrine functions of VD have been described, including a prominent role on carcinogenesis. In recent years, multiple associations between VD deficiency and different types of cancer have...

The XPD gene product has a dual function in basal transcription and in nucleotide excision repair. We have previously reported that two polymorphisms in the gene, one silent mutation in codon 156 of exon 6 and one giving rise to a Lys-->Gln substitution in codon 751 of exon 23, showed signs of being associated with basal cell carcinoma in a Scandinavian study group of psoriasis patients and non...

Skin cancer is caused due to unusual development of skin cells and deadly type cancer. Early diagnosis very significant can avoid some categories cancers, such as melanoma focal cell carcinoma. The recognition the classification malignant growth in beginning time expensive challenging. deep learning architectures recurrent networks convolutional neural (ConvNets) are developed past, which prove...

Non-melanoma skin cancers are the most commonly diagnosed forms of cancer in Canada (approximately 72,000 cases across the country in 2002). After this type of skin cancer, prostate, breast, colorectal, and lung cancers are the most frequently diagnosed and account for 56% (57% provincially) of total reported cancer cases in Waterloo Region within the past five years. They are also the leading ...

Abstract Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol a triterpenoid isolated from Ganoderma lucidum known to have various biological functions, including antibacterial effects. However, anti-cancer effects mechanism action lucidadiol in malignant melanoma are unknown. In this study, significantly reduced B16 cell viability dose- time-dependent manner. addition, in...

Skin cancer is the most common form of affecting humans. Melanoma dangerous type skin cancer; and early diagnosis extremely vital in curing disease. So far, human knowledge this field very limited, thus, developing a mechanism capable identifying disease on can save lives, reduce intervention cut unnecessary costs. In paper, researchers developed new learning technique to classify lesions, with...

Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk ...

Pigmented Bowens disease is an in situ squamous cell carcinoma, which is seldom reported in white patients. Herein we report a 20-year-old woman with type III skin, who had this lesion on the fourth finger of her right hand, similar to superficial malignant melanoma, clinically. Although dermoscopic evaluation could be helpful, correct diagnosis of non-melanotic origin is done by histological e...

introduction: the incidence of malignant melanoma is increasing at a rate greater than any other human cancer. although melanoma accounts for only 4 percent of all dermatologic cancers, it is responsible for 80 percent of deaths from skin cancer; only 14 percent of patients with metastatic melanoma survive for five years. the optimal therapy varies with the stage of the disease. surgical excisi...