This study aimed to examine the associations between serious illness in earlier life and risk of pain in old age using data from a large nationally representative British birth cohort, the Medical Research Council (MRC) National Survey of Health and Development (NSHD). Serious illness was defined as any experience of illness before age 25 requiring hospital admission of ≥28 days. Pain was self-...

PURPOSE Tumor-infiltrating macrophages are associated with adverse outcome in adult classical Hodgkin lymphoma (cHL). We have previously shown age-related changes in the lymphocyte composition of pediatric cHL. We therefore hypothesized that the number, function, and prognostic impact of macrophages in pediatric cHL would be different from adult cases. EXPERIMENTAL DESIGN We analyzed the numb...

Recent studies have suggested that Epstein-Barr virus (EBV) may play a role in the etiology of Hodgkin's disease (HD). In a previous study, we used a latent membrane protein 1 (LMP1)-specific antibodies to examine archival material from 74 British children with HD and found 50% of cases to be positive. It is known that there are geographic and ethnic variations in the incidence of HD. We have i...

Purpose: Tumor-infiltrating macrophages are associated with adverse outcome in adult classical Hodgkin lymphoma (cHL).We have previously shown age-related changes in the lymphocyte composition of pediatric cHL. We therefore hypothesized that the number, function, and prognostic impact of macrophages in pediatric cHL would be different from adult cases. Experimental Design:We analyzed the number...

AIM To corroborate and investigate the nature of Hodgkin/Reed-Sternberg cells (H/R-S) of various subtypes of Hodgkin's disease. METHOD Single H/R-S cells were micro-picked from frozen sections of tissues affected by Hodgkin's disease. The DNA from these cells was amplified by the polymerase chain reaction (PCR) with immunoglobulin heavy chain (IgH) gene FRIIIa/JH primers and light chain gene ...

PURPOSE Serum levels of the inflammatory markers YKL-40 and interleukin 6 (IL-6) are increased in many conditions, including cancers. We examined serum YKL-40 and IL-6 levels in patients with Hodgkin lymphoma, a tumor with strong immunologic reaction to relatively few tumor cells, especially in nodular sclerosis Hodgkin lymphoma. EXPERIMENTAL DESIGN We analyzed Danish and Swedish patients wit...

The solitary, nodular lesions of the oral mucosa present a diagnostic dilemma to the dentist with their analogous presentation. The lesions that appear on the tongue, a soft muscular organ are distinct and even rarer with varied manifestations. Oral mucosa presents lesions of the tongue in all age groups that may range from a small nodular swelling and ulcer formation in an infant of a few days...

a swelling on the back of his head. He stated that five months ago, i.e., in January 1938, he noticed a small nodular swelling in the occipital region. At that time it was painless and so he did not pay any attention to it, but during the two following months the nodule had grown in size and had become slightly painful. He therefore went to a hakim and had the tumour cut by him?some time in Feb...

BACKGROUND We report a patient with Salzmann's nodular degeneration in whom the disease occurred without a history of keratitis and recurred twice after keratectomy. CASE A unilateral case of symptomatic Salzmann's nodular degeneration developed after cataract surgery in a 75-year-old woman. OBSERVATIONS We performed superficial keratectomy and amniotic membrane transplantation two times, b...

Nine rock types including Sandstone, Limestone, Siltstone, Dolomite and Marl collected from six different rock formations of the Salt Range area of Pakistan were tested to evaluate the correlations between the uniaxial compressive strength and the corresponding values of the point load index. Two hundred rock cores were drilled and used for the uniaxial compressive strength and point load index...