REPLY: In a recent commentary, Baumgärtner and Treede question the conclusion of our recent study, in which we show that laser-evoked brain potentials (LEPs) are not able to isolate nociceptive-specific cortical processing (Mouraux and Iannetti 2009). Here, we will show that the three points raised by Baumgärtner and Treede are unjustified and that our conclusion is entirely valid. 1. Baumgärtn...

background and objective: due to the presence of some evidence for anti-diabetic and antioxidant activity of tribulus terrestris (tt), this study was designed to investigate the anti-nociceptive effect of tt in streptozotocin-diabetic rats using formalin test and hot tail immersion tests. materials and methods: rats were divided into control, tt-treated control, diabetic, sodium salicylate (ss)...

Painful diabetic neuropathy is a common complication of diabetes mellitus and can affect many aspects of life and severely limit patients' daily functions. Signals of painful diabetic neuropathy are believed to originate in the peripheral nervous system. However, its peripheral mechanism of hyperalgesia has remained elusive. Numerous studies have accumulated that polymodal nociceptive C-fibres ...

Recordings were made from single SI cortical neurons in the anesthetized macaque monkey. Each isolated cortical neuron was tested for responses to a standard series of mechanical stimuli. The stimuli included brushing the skin, pressure, and pinch. The majority of cortical neurons responded with the greatest discharge frequency to brushing the receptive field, but neurons were found in areas 3b...

introduction: mineral trioxide aggregate (mta) is an endodontic material with different clinical applications e.g. root-end filling, pulp capping and perforation repair.  it has been reported to possess antimicrobial and antifungal activities. the aim of this study was to examine the effect of white mta on formalin-induced hyperalgesia in a rat with inflammatory pain. materials and methods: inf...

AIM To review pharmacological management of chronic low back pain (LBP), with respect to management of nociceptive and neuropathic components. METHODS Studies were identified by a PubMed search of English-language papers from the last 10  years, with additional hand searches of relevant reviews. DISCUSSION Paracetamol, non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 inhibitors t...

Plants from the genus Phyllanthus like Phyllanthus muellerianus have long been used in folk medicine for several ailments including fevers, toothache, dysmenorrhea, anemia and paralysis. Despite these folkloric uses, there is little scientific data supporting the use of this plant in the management of pain. The purpose of this study is to evaluate the aqueous extract of the aerial parts of Phyl...

Neuropathic pain results from neuroplasticity in nociceptive neuronal networks. Here we demonstrate that control of alternative pre-mRNA splicing, through the splice factor serine-arginine splice factor 1 (SRSF1), is integral to the processing of nociceptive information in the spinal cord. Neuropathic pain develops following a partial saphenous nerve ligation injury, at which time SRSF1 is acti...

INTRODUCTION Research has shown that people with chronic pain have difficulty directing their attention away from pain. A mental strategy that incorporates focused attention and distraction has been found to modulate the perception of pain intensity. That strategy involves placing attention on the nociceptive stimulus felt and shifting attention to a self-generated sub-nociceptive image and reh...