RESUMO Objetivo: descrever as estratégias para minimizar o efeito nocebo na comunicação em saúde. Métodos: trata-se de uma revisão integrativa da literatura. Os descritores utilizados foram: “Efeito nocebo” e “comunicação saúde”, inglês, português espanhol suas combinações, no período 2011 a 2021, nas bases dados Medline, Literatura Latino-Americana do Caribe Ciências Saúde (LILACS), Cochrane L...

Evidence from clinical studies emphasizes the relevance of contextual psychosocial variables, including physicianpatient interactions, for treatment outcome [1]. Positive psychosocial infl uences on treatment outcomes are termed placebo eff ects, whereas negative infl uences are termed nocebo eff ects. Experimental research reveals that the psychosocial context of therapy induces biochemical ch...

BACKGROUND Studies suggest that expectations powerfully shape clinical outcomes. For subjective outcomes in adequately blinded trials, health improvements are substantial and largely explained by non-specific factors.The objective of this study was to investigate if unblinding in randomized controlled trials (RCTs) is associated with enhanced placebo effects for intervention groups and nocebo e...

Background: Placebo and nocebo responses have important consequences for the development of pharmaceutical drugs design randomized controlled trials (RCTs). They can lead to incorrect measurement treatment-related efficacy adverse effects (AEs). Objectives: The goal this study was evaluate frequency magnitude placebo in placebo-controlled RCTs non-tumor necrosis factor (TNF) biologics Janus kin...