Nitro-fatty acids are reactive signaling mediators that are formed when unsaturated fatty acids react with nitric oxide or nitric oxide-derived species. Nitro-fatty acids can modify specific signaling pathways via post-translational modifications of Cys residues in key regulatory proteins. One of the signaling cascades activated by nitro-fatty acids is the Keap1-Nrf2 pathway. We have previously...

Chloride permeation through the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel is blocked by a broad range of anions that bind tightly within the pore. Here we show that the divalent anion Pt(NO2)42- acts as an impermeant voltage-dependent blocker of the CFTR pore when added to the intracellular face of excised membrane patches. Block was of modest affinity (apparent Kd ...

With the increasing availability of observational data from different sources at a global level, joint analysis of these data is becoming especially attractive. For such an analysis – oftentimes with little prior knowledge about local and global interactions between the different observational variables at hand – an exploratory, data-driven analysis of the data may be of particular relevance. I...

[1] We used SCIAMACHY (10:00 LT) and OMI (13:30 LT) tropospheric NO2 columns to study diurnal and seasonal patterns in NO2 concentrations over India. Using characteristics of seasonal variability in tropospheric NO2 columns, we present a simple methodology to identify the dominant NOx source category for specific regions in India. Regions where the dominant source category is classified as biom...

Corresponding Author: Zhiwei Chen School of Life Sciences, Shandong University of Technology, 255049, Zibo, China Tel: +86-05332786781, Fax: +86-05332786781 Email: [email protected] Abstract: In this study, the anions nitrite ion (NO2 ) and nitrate ion (NO3 ) in celeries and carrots were detected with the technique of ion chromatography. A Dionex ICS-2000 ion chromatograph was used to detect the c...

introduction no2 is not only a potential air pollutant in urban and industrial environments but also a precursor for smog of urban environment that is another ozone pollutant as well. some of the urban environments in iran have high tropospheric and near surface no2 which requires research attentions especially in these years. that is the issue of concern in the present study using satellite da...

Ground-based measurements of scattered sunlight by the Multi Axis Differential Optical Absorption Spectroscopy (MAX-DOAS) have been carried out at an urban site (39.95 N, 116.32 E) in Beijing megacity since 6 August 2008. In this study, we retrieved the tropospheric NO2 vertical column densities (VCDs) over Beijing from these MAX-DOAS observations from August 2008 to September 2011. Over this p...

Nitrogen oxides (NO+NO2=NOx and reservoir species) are important trace gases in the troposphere with impact on human health, atmospheric chemistry and climate. Besides natural sources (lightning, soil emissions) and biomass burning, fossil fuel combustion is estimated to be responsible for about 50% of the total production of NOx. Since human activity in industrialized countries largely follows...

Aldehydes are an important class of products from atmospheric oxidation of hydrocarbons. Isoprene (2methyl-1,3-butadiene), the most abundantly emitted atmospheric non-methane hydrocarbon, produces a significant amount of secondary organic aerosol (SOA) via methacrolein (a C4-unsaturated aldehyde) under urban high-NOx conditions. Previously, we have identified peroxy methacryloyl nitrate (MPAN) ...