Candida glabrata is the second most common organism isolated from women with vulvovaginal candidiasis (VVC), particularly in women with uncontrolled diabetes mellitus. However, mechanisms involved in the pathogenesis of C. glabrata-associated VVC are unknown and have not been studied at any depth in animal models. The objective of this study was to evaluate host responses to infection following...

Although learning a second language (L2) as an adult is notoriously difficult, research has shown that adults can indeed attain native language-like brain processing and high proficiency levels. However, it is important to then retain what has been attained, even in the absence of continued exposure to the L2--particularly since periods of minimal or no L2 exposure are common. This event-relate...

OBJECTIVE To investigate cerebellar gray matter volume in patients with essential tremor (ET). METHODS We used voxel-based morphometry (VBM) based on high-resolution T1-weighted MRI to compare gray and white matter density between 27 patients with ET and 27 age- and sex-matched healthy control subjects. Fourteen patients had only postural tremor, whereas 13 patients showed additional intentio...

Q systems with scheduled arrivals, i.e., appointment systems, are typical for frontal service systems, e.g., health clinics. An aspect of customer behavior that influences the overall efficiency of such systems is the phenomenon of no-shows. The consequences of no-shows cannot be underestimated; e.g., British surveys reveal that in the United Kingdom alone more than 12 million general practitio...

This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrollment and blood donation, 21 of whom have developed prostate cancer whilst on study....

BACKGROUND AND OBJECTIVES Missed appointments can create financial, capacity, and continuity issues in primary care. An urban family medicine residency teaching clinic with a large culturally diverse population of low-income patients struggled for decades with a persistent no-show rate of 15%--17% despite multiple attempts to remind patients or otherwise address the problem. This study sought t...

We consider queueing systems where a finite number of customers arrive over time to a service system, consisting of either a single or multiple servers. The arrival of customers is driven by appointments, with a scheduled appointment time associated with each customer. However, customers are not necessarily punctual and may arrive either earlier or later than their scheduled appointment times. ...

We consider a single-server scheduling problem given a fixed sequence of job arrivals with random noshows and service durations. The joint probability distribution of the uncertain parameters is assumed to be ambiguous and only the support and first moments are known. We formulate a class of distributionally robust optimization models that incorporate the worst-case expected cost and the worst-...

First Do No Harm' is a series of 12 brief monthly articles with internet footnotes about harming and healing in general practice. Each instalment is based on one of the 12 RCGP competency domains, this month's being: 11. Maintaining an ethical approach to practice: practising ethically with integrity and a respect for diversity. 1 'The true aim of medicine is not to make men virtuous; it is to ...

Calcium and iron overload participate in the mechanisms of ischemia/reperfusion (I/R) injury during myocardial infarction (MI). Calcium overload induces cardiomyocyte death by hypercontraction, while iron catalyses generation of reactive oxygen species (ROS). We therefore hypothesized that dexrazoxane, an intracellular metal chelator, would attenuate I/R injury. MI was induced in pigs by occlus...