WCET calculus is nowadays a must for safety critical systems. As a matter of fact, basic real-time properties rely on accurate timings. Although over the last years, substantial progress has been made in order to get a more precise WCET, we believe that the design of the underlying frameworks deserve more attention. In this paper, we are concerned mainly with two aspects which deal with the mod...

Background Elevated baseline (BL) C-reactive protein (CRP) levels can predict treatment response in patients (pts) with ankylosing spondylitis (AS). Tofacitinib is a Janus kinase inhibitor for the of AS. Objectives To evaluate impact BL CRP on tofacitinib efficacy and safety pts Methods Post hoc analysis pooled data from placebo (PBO)-controlled, randomised, double-blind trials ( NCT01786668 , ...

The theoretical and computational framework of finite deformation mesoscale field dislocation mechanics (MFDM) is used to understand the salient aspects kink-band formation in Cu-Nb nano-metallic laminates (NMLs). A conceptually minimal, plane-strain idealization three-dimensional geometry, including crystalline orientation, additively manufactured NML model NMLs. Importantly, natural jump/inte...

In this paper, we analyze the performance of a non-data aided near maximum likelihood (NDA-NML) estimator for symbol timing recovery in wireless communications. The performance of the estimator is evaluated for an additive noise only channel. Performance analysis is extended to fading channels characterized by Rayleigh fading, Weibull fading and log-normal fading, appropriate to a variety of tr...

A mouse brain genomic library cloned in lambda 2001 was sequences which are described to act as regulatory elements (3). screened with a rat somatostatin cDNA probe (1). A 22.5 Kb fragment was isolated and subcloned in pEMBL 18 plasmid. REFERENCES A 2564 bp insert, sequenced by the dideoxy method of Sanger (2), contains a 116 amino acids preprosomatostatin coding region. ' Goodman.R H , Jacobs,...

New parallel architectures are emerging to meet the increased computational demands of streaming applications. This creates a need for high-level, architecture-independent languages. One such language is StreamIt, designed around the notions of streams and stream transformers, which allows efficient mapping to a variety of architectures. This paper presents our approach of compiling StreamIt ap...

We describe an approach to hardware/software co-design that starts with a high-level specification of a target machine and a synchronous data flow representation of an algorithm. The instruction set description is translated into a netlist-level machine description. A set of independent tools successively transform the algorithm into a program for the target processor. We employ the machine des...

We introduce a retargetable microcode generator for application specific digital signal processors (ASDSPs). The primary goal of our work is to quickly provide system architects with the set of tools necessary for program development (assemblers, instruction set simulators, debuggers and compilers); in particular when the processor architecture is refined simultaneously with the algorithm. Afte...

This paper presents a method based on fitting a sum-of-exponentials model to the nonuniformly sampled data, for clustering the time series of gene expression data. The structure of the model is estimated by using the minimum description length (MDL) principle for nonlinear regression, in a new form, incorporating a normalized maximum-likelihood (NML) model for a subset of the parameters. The pe...

One of the open problems in the philosophy of information is whether there is an information logic (IL), different from epistemic (EL) and doxastic logic (DL), which formalises the relation “a is informed that p” (Iap) satisfactorily. In this paper, the problem is solved by arguing that the axiom schemata of the normal modal logic (NML) KTB (also known as B or Br or Brouwer’s system) are well s...