نتایج جستجو برای: nitroimidazoles
تعداد نتایج: 352 فیلتر نتایج به سال:
Trichomonas vaginalis (Tv) is a causative agent of worldwide spread sexually transmitted disease, particularly affecting underdeveloped all segments of the population. Metronidazole is by far the most prescribed drug for the treatment of trichomoniasis. However, the appearance of drug resistant has led to the appearance of new drug alternatives. That is why the development of reliable and stand...
A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1H-imidazole under microwave heating was developed. This method is applicable to a wide range of (hetero)arylboronic acids and terminal alkynes. Additionally, this approach provides a simple and efficient way to synthesize 2,4-disubstituted 5-nitroimidazole derivatives with antibac...
A strain of Trichomonas vaginalis (IR-78), recently isolated from a patient afflicted with recurrent symptomatic trichomoniasis, showed resistance to metronidazole, tinidazole, and nimorazole in vitro as well as in vivo. In a serial dilution test using cysteine monohydrochloride-peptone-liver infusion-maltose medium, T. vaginalis IR-78 was only resistant under aerobic conditions. Under anaerobi...
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