Almost 20 years has passed since trichomonosis was first recognized as a potential cause of diarrhea in domestic cats. Despite progress in confirming disease causation, developing means for diagnosis, and identifying approaches to treatment of the infection, we still know very little about how this parasite causes diarrhea. With increasing recognition of resistance of trichomonosis to treatment...

Introduction: Hypoxic regions in tumors are known to affect radiation sensitivity and promote development of metastases [1]. Noninvasive imaging based methods such as MRI are particularly suitable for longitudinal measurements and generation of three-dimensional spatial maps of tumor hypoxia [2]. An MRI method that could differentiate hypoxic versus normoxic tissues without relying on washout m...

A new anti-protozoal compound, ornidazole, a derivative of nitroimidazole, was given in a single 2 g dose to 20 women with Trichomonas vaginalis infection. All the women were cured, but they suffered some side-effects. Plasma levels of ornidazole reached a peak five to eight times higher than minimum inhibitory concentrations and exceeded this level for at least 36 hours. It is therefore possib...

ronidazole. The reduction of the nitro group to the amine cesults in the total loss of mutagenic activity. Furthermore, once the amine is formed, it is not re-activated like those of other aromatic amines. In conclusion, the major ronidazole-protein adduct contains a reduced nitro function, has lost the carbamoyl group, and is alkylated by cysteine at the 2-methylene or 4-position. These struct...

Bacterial vaginosis (non-specific vaginitis) is a mild but common condition. O'Dowd et al reported that organisms associated with vaginosis could be isolated from 37% of women who presented with vaginal symptoms. The current treatment of choice is an oral nitroimidazole (metronidazole or tinidazole), given either as a single large dose or as a twice daily regimen for five to seven days. A probl...