CYTOTOXIC compounds act by combining with the biochemical constituents of cells. Because of the complexity of living matter, the cytotoxic activity is highly complicated in nature and is therefore far from being thoroughly understood. In order to analyse the cytotoxicity of any chemical compound, many biological variables concerned in determining the mode of action of the compound and its selec...

WAY-100635 is widely used in vitro and in vivo as an antagonist of 5-HT 1A receptors [1]. In terms of pharmacological tools and pharmacological investigations, the ideal reference molecule would be highly selective for its target over other related and non-related targets. However WAY-100635 displays affinity for and activity at D 4 dopamine receptors, and that "off-target" activity confounds i...

In recent years, the ability of cold atmospheric pressure plasmas (CAPS) to selectively induce cell death in cancer cells has been widely established. This selectivity has been assigned to the reactive oxygen and nitrogen species (RONS) created in CAPs. To provide new insights in the search for an explanation for the observed selectivity, we calculate the transfer free energy of multiple ROS ac...

Aquaporins of the TIP subfamily (Tonoplast Intrinsic Proteins) have been suggested to facilitate permeation of water and ammonia across the vacuolar membrane of plants, allowing the vacuole to efficiently sequester ammonium ions and counteract cytosolic fluctuations of ammonia. Here, we report the structure determined at 1.18 Å resolution from twinned crystals of Arabidopsis thaliana aquaporin ...

Separation of volatile fatty acids (VFAs) from fermented wastewater is challenging, due to low VFA concentrations in mineral-rich streams. As a result, separation capacity and selectivity with traditional solvents and adsorbents are both compromised. In this study, using a complex artificial model solution mimicking real fermented wastewaters, it is shown that a simple and robust adsorption-bas...

Series of Copper Ruthenium (Cu-Ru) bimetallic catalysts supported on γ-Al2O3 with different metal loading are prepared and investigated for catalytic wet air oxidation of ammonia to nitrogen. The ammonia decomposition activity was studied at three different temperatures i.e. 150oC, 200oC, and 230 oC and it is found that catalytic activity increases with the increase in temperature along with th...

the efficient detection of charged biomolecules by biosensor with appropriate semiconducting nanomaterials and with optimum device geometry has caught tremendous research interest in the present decade. here, the performance of various label-free electronic biosensors to detect bio-molecules is investigated by simulation technique. silicon nanowire sensor, nanosphere sensor and double gate fiel...

• Metal nanostructures on nitrogen-doped carbon studied in CH 2 X hydrodehalogenation. Nanoparticle-based systems provide the highest catalytic activity and stability. Selectivity to target 3 depends active phase size halogen type. Ir single atoms compete with best reported Cl hydrodechlorination catalysts. Adsorption dissociation energies of H govern performance. Nanostructuring metal catalyst...

The activation of heteromeric and homomeric nicotinic acetylcholine receptors was studied in Xenopus laevis oocytes to identify key structures of putative agonist molecules associated with the selective activation of homomeric alpha7 receptors. We observed that selectivity between alpha7 and alpha4beta2 was more readily obtained than selectivity between alpha7 and alpha3beta4. Based on structur...

BACKGROUND AND AIMS Thesium chinense is a hemiparasitic plant that is common in grassland habitats of eastern Asia. Although the physiology of Thesium has been well studied in attempts to control its weedy habit, there have been few ecological investigations of its parasitic life history. Thesium chinense is thought to parasitize species of Poaceae, but evidence remains circumstantial. METHOD...