When chloramphenicol is administered by mouth to normal human subjects, only 5 to 10 per cent of the administered dose is excreted unchanged in the urine, as determined by microbiological assay methods (3, 4). However, with calorimetric methods for aromatic nitro compounds (5), from 75 to 90 per cent of the administered dose is accounted for in 24 hour urinary excretion in man (3). The major po...

Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-2-(l-methyl-5-nitro-2-imidazo1yl)-4.- methyl-(or phenyl-) quinolines (14) were prepared through the reaction of 2- acetyl-5-nitro-1-methy...

In the present study, an appropriate synthetic route was adopted to produce the target synthesis of Juglone. In the first of these objectives, 5-nitro-1,4-naphthoquinone had been synthesized by direct nitration of 1,4-naphthoquinone in the presence of water and sulfuric acid. Then the intermediate synthesis of 5-amino-1,4-naphthoquinone was obtained by the reduction of nitro. Finally, Juglone w...

The structure, charge distribution and electronic coupling between the functional groups, caused by the conversion of two main nitrobenzenes (pand m-dinitrobenzene) into radical anions was studied at B3LYP/6-311++G** level. The vibrational spectra of the neutral compounds and the radical anions, which are closely related to the structural and electronic changes, were also studied and discussed....

This study was designed for assessment of 3 types of Cysteine protease inhibitors (CPIs) fluromethylketone (FMK), vinyl sulfone (VS) and sodium nitro prussid (SNP), to define which of them is the best for curing S. mansoni infection in mice? In vitro, treated S. mansoni adult worms recorded a mortality rate after 1 hr of exposure to 500 ppm of FMK, VS and SNP as 75, 70 and 60%, respectively. FM...

Treatment of mouse skin with pentachloronitrobenzene and each of the 3 tetrachloronitrobenzenes resulted in multiple papilloma formation during subsequent treatment with croton oil. The highest yield of papillomas was obtained with 2,3,4,5-tetrachloronitrobenzene, the only compound of the 4 that has a stable nitro group and does not give rise to appreciable mercapturic acid in the rabbit. It is...

A new chemoselective reductive nitro-Mannich cyclization reaction sequence of nitroalkyl-tethered lactams has been developed. Relying on the rapid and chemoselective iridium(I)-catalyzed reduction of lactams to the corresponding enamine, subsequent nitro-Mannich cyclization of tethered nitroalkyl functionality provides direct access to important alkaloid natural-product-like structures in yield...

In the rabbit 2:3:5:6-tetrachloronitrobenzene is metabolized by reduction of the nitro group, hydroxylation and mercapturic acid formation (Bray, Hybs, James & Thorpe, 1953). The last reaction is of particular interest since it is accompanied by loss of a nitro group directly attached to the benzene ring. Two further examples of this type of reaction were encountered when pentachloronitrobenzen...

Since FOX-7 (1, 1-diamino-2, 2-dinitroethylene) is a relatively new energetic material, little is known about its physical and chemical properties. Therefore, first-principles quantum chemical calculations are used to predict the energies of atoms of FOX-7. Under gentle heating (thermolysis) is likely to cause hydrogen transfer between molecules, producing highly reactive chemical species. Conv...