In our previous work, genomic data generated through non‑invasive prenatal testing (NIPT) based on low‑coverage massively parallel whole‑genome sequencing of total plasma DNA pregnant women in Slovakia was described as a valuable source population specific data. the present study, these were used to determine allele frequency common risk variants located genes associated with colorectal cancer ...

In this article, we discuss the radical uncertainties unleashed by expanded prenatal genetics. We show how are now routinely screening fetuses in absence of two essential sorts information. At population level, do not have sound, unbiased data about prevalence, penetrance, and clinical variability most mutations. level proband, it is often too soon to discern relevant information fetus’ phenoty...

Related Articles Anomalous Hall effect in NiPt thin films J. Appl. Phys. 110, 033909 (2011) Insulator-quantum Hall conductor transition in high electron density gated InGaAs/InAlAs quantum wells J. Appl. Phys. 108, 063701 (2010) Theory of quantum phase transitions in dimerized antiferromagnets Low Temp. Phys. 36, 665 (2010) Seeing emergent phases in quantum Hall double layers J. Appl. Phys. 101...

Non-invasive prenatal testing (NIPT) by random massively parallel sequencing of maternal plasma DNA for multiple pregnancies is a promising new option for prenatal care since conventional non-invasive screening for fetal trisomies 21, 18 and 13 has limitations and invasive diagnostic methods bear a higher risk for procedure related fetal losses in the case of multiple gestations compared to sin...

BACKGROUND X&Y chromosomal aneuploidies are among the most common human whole-chromosomal copy number changes, but the population-based incidence and prevalence in the child-bearing population is unclear. METHODS This retrospective analysis of prospectively collected data leveraged a routine non-invasive prenatal test (NIPT) using parental genotyping to estimate the population-based incidence...

The urinary metabolites of 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) in humans have been investigated by analyzing urine specimens from its users. For the unequivocal identification and accurate quantification of its major metabolites, careful analyses were conducted by gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry, and liquid chromatography-tandem mass sp...