BACKGROUND The aim of this study was to develop an optimal niosomal system to deliver Ginkgo biloba extract (GbE) with improved oral bioavailability and to replace the conventional GbE tablets. METHODS In this study, the film dispersion-homogenization method was used to prepare GbE niosomes. The resulting GbE niosome suspension was freeze-dried or spray-dried to improve the stability of the n...

Pharmacosomes are colloidal dispersions of drugs covalently bound to lipids, and may exist as ultrafine vesicular, micellar, or hexagonal aggregates, depending on the chemical structure of drug-lipid complex. It is based on the principle that the drug binds covalently to a lipid where the resulting compound is the carrier and the active compound at the same time. The physicochemical properties ...

The objective of this study was to develop an efficient ocular nanovesicular carrier providing a controlled delivery of Clotrimazole (CLT); a water insoluble antifungal drug. The nanovesicular carriers were formulated using Span 60 with one of the following edge activators (EA): Tween 80 (TW80), sodium cholate (SC) or sodium deoxycholate (SDC). A 3(2) full factorial design was used to study the...

Over the past years the treatments of disease have undergone a revolutionary change. With the advancement of pharmaceutical science not only novel drug delivery system have been developed but also emphasis has been laid to deliver the active constituent to the diseased site.The basic component of such a system is a suitable carrier that protects the active medicament from degradation or clearan...