Resorbable polymeric implants and surface coatings are an emerging technology to treat bone defects and increase bone formation. This approach is of special interest in anatomical regions like the calvaria since adults lose the capacity to heal large calvarial defects. The present study assesses the potential of extracellular matrix inspired, embroidered polycaprolactone-co-lactide (PCL) scaffo...

To examine the influence of substrate topology on the behavior of fibroblasts, tissue engineering scaffolds were electrospun from polycaprolactone (PCL) and a blend of PCL and gelatin (PCL+Gel) to produce matrices with both random and aligned nanofibrous orientations. The addition of gelatin to the scaffold was shown to increase the hydrophilicity of the PCL matrix and to increase the prolifera...

Hemocompatibility, anti-inflammation and anti-thrombogenicity of acellular synthetic vascular grafts remains a challenge in biomaterials design. Using electrospun polycaprolactone (PCL) fibers as a template, a coating of polypyrrole (PPy) was successfully polymerized onto the fiber surface. The fibers coated with heparin-doped PPy (PPy-HEP) demonstrated better electroactivity, lower surface res...

Objective: To investigate the effects of growth factors fibroblast-derived extracellular matrix formation in the 3D fiber-deposited polycaprolactone (PCL) scaffold fabricated by 3D printing technique for tissue engineering applications of tunica albuginea. Methods: PCL scaffold was fabricated by 3D bioprinting system. For in vitro cell study, scaffolds were seeded with human fibroblast cell at ...

Standard dialyzer membranes, designed for diffusive clearance, do not effectively clear protein-bound uremic toxins, such as indoxyl sulfate (IS). To increase toxins removal, absorbents require a high specific surface area to achieve effective size-coupling removal of target toxins. However, the toxicity molecule is necessarily determined by size alone. As proof concept, we report on an electro...

There are a few shape memory polymers (SMPs) like polylactic acid (PLA) and polyurethane (PU) that 4D printable, other SMPs must be synthesized with complicated chemical lab effort. Herein, considering dual-material extrusion printing microscopic mechanism behind effect (SME), bilayer-encapsulated polycaprolactone (PCL)–thermoplastic (TPU) composite structures printed for the first time. The SM...

In this study, nanocomposites based on polycaprolactone (PCL) and two types of mesoporous silicas, MCM-41 SBA-15, were attained by melt extrusion. The effect the silica incorporated within PCL matrix was observed, firstly, in morphological characteristics degradation behavior resultant composites. DSC experiments provided information existence confinement PCL–SBA-15 materials through appearance...

aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (pcl), poly (vinyl alcohol) (pva) and hydroxyapatite nanoparticles (nha). the morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...

In this study, vascular stents were fabricated from poly (lactide-ɛ-caprolactone)/collagen/nano-hydroxyapatite (PLCL/Col/nHA) by electrospinning, and the surface morphology and breaking strength were observed or measured through scanning electron microscopy and tensile tests. The anti-clotting properties of stents were evaluated for anticoagulation surfaces modified by the electrostatic layer-b...

The mechanical properties of electrospun nanofiber membranes are critical for their applications. A clear understanding of the mechanical properties that result from the characteristics of the individual fiber and membrane microstructure is vital in the design of fiber composites. In this reported study, silk fibroin (SF)/polycaprolactone (PCL) composite nanofiber membranes were preparedusing a...