Nickel (II), a ubiquitous environmental and industrial contaminant, is a well-known human carcinogen, particularly in human lung cancer. Although by itself it is a weak mutagen, nickel (II) is able to significantly enhance the genotoxicity of other mutagens and carcinogens, such as polycyclic aromatic hydrocarbons (PAHs) and ultraviolet light. Certain human populations, especially cigarette smo...

Escherichia coli NikR regulates cellular nickel uptake by binding to the nik operon in the presence of nickel and blocking transcription of genes encoding the nickel uptake transporter. NikR has two binding affinities for the nik operon: a nanomolar dissociation constant with stoichiometric nickel and a picomolar dissociation constant with excess nickel [Bloom, S. L., and Zamble, D. B. (2004) B...

Andrew, Angeline S., Linda R. Klei, and Aaron Barchowsky. Nickel requires hypoxia-inducible factor-1a, not redox signaling, to induce plasminogen activator inhibitor-1. Am J Physiol Lung Cell Mol Physiol 281: L607–L615, 2001.—Human epidemiological and animal studies have associated inhalation of nickel dusts with an increased incidence of pulmonary fibrosis. At the cellular level, particulate n...

N ickel is a potentially allergenic material. It is one of the most common causes of allergic contact dermatitis, particularly in women. l-5 Nickel can also be considered an occupational allergen. Nickel contact dermatitis is common among industrial workers, especially in those industries that use nickel as a raw material. It has been demonstrated that U.S. S-cent coins contain approximately 25...

one of the most important stages in sugar industry that making wastewater and contamination is the water obtained to washing of co2 in mazoot furnace and related pumps. amount of water consumption in this stage is about 30 to 35 percent of weight of sugar beet, so amount of this stream is considerable. mixing of carbon black and water compose the colloid in liquid phase. these colloids do not s...

Nickel was measured by atomic absorption spectrometry in three-day collections of feces from healthy hospital workers (age 22-65) who had lived for more than a year ‘in Hartford, Connecticut. None of the 10 subjects (4 , 6j9.) had occupational exposure to nickel. Fecal nickel averaged 3.3 gzg/g (wet weight); SD, ±0.8; and range, 2.1 to 4.4 tg/g. Corresponding figures on a dry-weight basis were ...