Li, Xiao Xi, Frederick E. Albrecht, Jean E. Robillard, Gilbert M. Eisner, and Pedro A. Jose. Gb regulation of Na/H exchanger-3 activity in rat renal proximal tubules during development. Am J Physiol Regulatory Integrative Comp Physiol 278: R931–R936, 2000.—The decreased natriuretic action of dopamine in the young has been attributed to decreased generation of cAMP by the activated renal D1-like...

Miyata, Yukio, Shigeaki Muto, Satoru Yanagiba, and Yasushi Asano. Extracellular Cl2 modulates shrinkageinduced activation of Na1/H1 exchanger in rat mesangial cells. Am J Physiol Cell Physiol 278: C1218–C1229, 2000.—To examine the effect of hyperosmolality on Na1/H1 exchanger (NHE) activity in mesangial cells (MCs), we used a pHsensitive dye, 28,78-bis(2-carboxyethyl)-5(6)-carboxyfluorescein-AM...

Dopamine-induced inhibition of Na(+)-K(+)-ATPase has been suggested to play a role in the regulation of Na(+) absorption at the intestinal level, and these effects were mediated by dopamine D(1)-like receptors. The aim of this work was to evaluate the effect of the activation of the D(1)-like receptors on the activity of the Na(+)/H(+) exchanger (NHE) in the rat intestinal epithelial cell line ...

This study investigated the role of the Na(+)-H+ exchanger (NHE) on angiotensin II (Ang II)-induced activation of Na(+)-dependent Mg2+ transport in vascular smooth muscle cells (VSMCs) from Wistar-Kyoto rats (WKY; n=20) and spontaneously hypertensive rats (SHR; n=20). Intracellular free concentrations of Mg2+ ([Mg2+]i) and Na+ ([Na+]i) and intracellular pH (pHi) were measured with the specific ...

OBJECTIVE To evaluate the use of a Na/H exchanger (NHE-1) inhibitor as a cardioprotective adjunct therapy to low-volume resuscitation in two different rat models of traumatic hemorrhagic shock. DESIGN Experimental, prospective study. SETTING Medical center research laboratory. SUBJECTS Sprague Dawley male rats. INTERVENTIONS Series 1: femur fracture was induced in anesthetized rats, fol...

BACKGROUND The vasoactive peptide bradykinin (BK) acts as a potent growth factor for normal kidney cells, but there have been few studies on the role of BK in renal cell carcinomas. PURPOSE In this study, we tested the hypothesis that BK also acts as a mitogen in kidney carcinomas, and explored the effects of BK in human renal carcinoma A498 cells. METHODS The presence of mRNAs for BK B(1) ...

The inhomogeneous brightness distribution of BATSE detected gamma-ray bursts has been considered strong evidence for their cosmological origin. However, subclasses of gamma-ray bursts have been shown to have significantly more homogeneous brightness distributions. Pendleton et al. (1997) have found such a result for gamma-ray bursts with no detectable emission at energies >300 keV. Accordingly,...

Maitotoxin (MTX) is one of the most potent toxins known to date. It causes massive calcium influx and necrotic cell death in various tissues. However, the exact mechanisms underlying its cellular toxicity are not fully understood. In the present study, the roles of extracellular acidosis and the sodium hydrogen exchanger (NHE) in MTX-induced increase in intracellular Ca and subsequent cell deat...

The Na+/H+exchanger ( NHE-2) has been implicated in osmoregulation in the kidney, because it transports Na+ across the cell membrane and efficiently alters intracellular osmolarity. On hyperosmotic stress, NHE-2 mRNA increases in abundance in mouse inner medullary collecting duct (mIMCD-3) cells, suggesting possible transcriptional regulation. To investigate the molecular mechanism of potential...

McLean, Lee Anne, Shaheen Zia, Fredric A. Gorin, and Peter M. Cala. Cloning and expression of the Na1/H1 exchanger from Amphiuma RBCs: resemblance to mammalian NHE1. Am. J. Physiol. 276 (Cell Physiol. 45): C1025– C1037, 1999.—The cDNA encoding the Na1/H1 exchanger (NHE) from Amphiuma erythrocytes was cloned, sequenced, and found to be highly homologous to the human NHE1 isoform (hNHE1), with 79...