Accurate dating of marine sediments is essential to reconstruct past changes in oceanography and climate. Benthic foraminiferal oxygen isotope series from such record long-term global ice volume deep-water temperature. They are commonly used the Plio-Pleistocene correlate deep ocean records construct age models. However, continental margin settings often display much higher sedimentation rates ...

Abstract. Smear slide petrography has been a standard technique during scientific ocean drilling expeditions to characterize sediment composition and classify types, but presentation of these percent estimates track downcore trends in become less frequent over the past 2 decades. We compare semi-quantitative smear physical property (natural gamma radiation, NGR) solid-phase geochemical (calcium...

[structure: see text] A bimodal target-specific contrast agent based on a cyclic peptide containing the target-specific NGR sequence, gadolinium(III) diethylenetriaminepentaacetic acid (Gd(III)DTPA), and Oregon Green 488 (OG488) suitable for both MR imaging and optical imaging of angiogenesis is developed. The synthetic strategy for this target-specific contrast agent exploits the use of highly...

The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RIP) of p75NTR and find that p75NTR cleavage is required for MAG-induced RhoA ac...

NogoA, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein are CNS myelin molecules that bind to the neuronal Nogo-66 receptor (NgR) and inhibit axon growth. The NgR antagonist, soluble NgR1-Fc protein (sNgR-Fc), facilitates axon regeneration by neutralizing the inhibitory effects of myelin proteins in experimental models of CNS injury. Here we aim to investigate the ef...

Myelin-associated glycoprotein (MAG) is a sialic acid binding Ig-like lectin (Siglec) which has been characterized as potent myelin-derived inhibitor of neurite outgrowth. Two members of the Nogo-receptor (NgR) family, NgR1 and NgR2, have been identified as neuronal binding proteins of MAG. In addition, gangliosides have been proposed to bind to and confer the inhibitory activity of MAG on neur...

Abstract. The Eocene–Oligocene Transition (EOT) marks the onset of Antarctic glaciation and switch from greenhouse to icehouse climates. However, driving mechanisms precise timing EOT remain controversial mostly due lack well-dated stratigraphic records, especially in continental environments. Here we present a cyclo-magnetostratigraphic sedimentological study ∼ 7.6 Myr long lacustrine record s...

The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diabetes mellitus (T2DM) group (n = 93), impaired glucose regulation (IGR) (n = 90...