BACKGROUND Lichen planopilaris (LPP) and discoid lupus erythematosus (DLE) are the most common causes of lymphocytic primary cicatricial alopecia. The management of scarring alopecia can be difficult. The combination of clinical, dermoscopy and reflectance confocal microscopy (RCM), a noninvasive, high-resolution imaging technique, examinations have already been demonstrated to be useful for ch...

Introduction. Frontal fibrosing alopecia (FFA) is known as a lymphocytic primary cicatricial alopecia. The main characteristic of FFA progressive frontotemporal hairline recession. pathogenesis not completely understood. Destructing the stem cells epithelial hair follicles causes permanent loss and seems to be cause FFA. Studies have reported significantly decreased quality life in patients wit...

Cicatricial alopecias (CAs) are a disfiguring and difficult to treat types of hair disorder that associated with distressing scalp symptoms significant secondary morbidity, marked psychological impact, loss quality life. The purpose our study was generate proof-of-principle for fundamentally innovative strategy treating CAs by therapeutically targeting caveolin-1 (Cav1), which is the principal ...

Background Fibrosing alopecia in a pattern distribution (FAPD) is primary cicatricial considered subtype of lichen planopilaris (LPP). Objective The clinical and histopathological features, treatment response 24 female patients with FAPD were evaluated. Methods Demographic, clinical, data retrospectively collected. Results Twenty-four women included (mean age 60.7 years). mean Lichen Planopilar...

Hair loss is a common adverse event of long-term epidermal growth factor receptor (EGFR)-inhibitor anti-cancer treatment. This severe cutaneous side effect often leads to dose reduction or cessation the otherwise successful targeted therapy. Additionally, hair an important part one’s identity, and losing it can lead social isolation low quality life. Mouse models follicle-specific deletion EGFR...

A 10 year old boy presented to our hospital with nephrotic syndrome relapse and signs of steroid toxicity in the form of posterior capsular cataract, affection of linear growth and stage 2 hypertension, in addition to steroid induced adiposity and fungal infection of the scalp resulting in cicatricial alopecia. He was diagnosed as nephrotic syndrome 6 months back. He went into remission with st...