suggest that brain tumors might result from occupation, dietary and other personal and residential exposures, but studies of cell phone use and power frequency electromagnetic fields have found little to support a causal connection with brain tumors; caveats remain though [8] . Previous studies have reported inconsistent results regarding the effect of anthropometric and lifestyle factors on th...

In 2013, two discoveries—that alkylating agent chemotherapy prolongs survival when added to radiotherapy for patients with anaplastic oligodendroglial tumours with 1p19q codeletion, and that bevacizumab prolongs progression-free survival in patients with newly diagnosed glioblastoma—have dominated debate in neuro-oncology. These findings could help to define new standards of care in malignant g...

Angiogenesis is one of the classic and diagnostic features of glioblastoma. These newly formed blood vessels are typically tortuous, forming vascular glomeruli, and they are notable for the lack of the tight junctions and complete pericyte coverage. This leads to peritumoral edema and extravasation of intravenous contrast on computed tomography or magnetic resonance imaging. Because angiogenesi...

Since the 2005 publication of the randomized European Organization for Research and Treatment of Cancer/National Cancer Institute ofCancer trial that established concurrent radiotherapy (RT) and temozolomide for upfront treatment of glioblastoma (GBM),1 little progress has been made. Thus, itwas remarkablewhen the interim results for the EF-14 trial were published, documenting a 4.9-month incre...

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. Standard initial treatment consists of maximal surgical resection followed by concurrent radiotherapy and temozolomide chemotherapy and then at least six months of adjuvant temozolomide (in the absence of disease progression or unacceptable toxicity). However, nearly all tumors eventually recur, ultimately leadi...

s of the Ninth Scientific Meeting 230 the absorptive surfaces remains intact, and (3) because the blood does not coagulate in the organism, no blood clotting factors are mobilized, the danger of DIC is diminished. The functional results in a series of patients are fairly good. 30 Prognosis of Benign Cerebellar Astrocytoma in Children J. Szénάsy, F. Slowik National Institute of Neurosurgery, Bud...

TO THE EDITOR: The new Response Assessment in NeuroOncology (RANO) criteria for high-grade gliomas developed by Wen et al are an important step forward because disease assessment has always been difficult to achieve in neuro-oncology; moreover, the criteria should be considered of crucial importance in overcoming the present disadvantages of the classical Macdonald criteria. The latter criteria...

background: very few studies have utilized specific criteria to assess mental disorders in brain tumor patients. this study aimed to diagnose mental disorders in this population using dsm-iv (depression, sleep, and mood) criteria. methods: from march 2007 to july 2009, the surgically treated patients with intracranial neoplasm were included in the study. these patients were examined in an ambul...

The DNA repair protein O-methylguanine-DNA methyltransferase (MGMT) confers resistance to methylating and chloroethylating agents in pediatric medulloblastomaand glioma-derived cell lines and xenografts. Here, we assayed MGMT activity in 110 pediatric brain tumors to establish correlates with patient and tumor characteristics. We also assayed MGMT in histologically normal brain adjacent to 22 t...

The DNA repair protein 06-methylguanine-DNA methyltransferase (MGMT) confers resistance to therapeutic methylating and chloroethylating agents in human brain tumor-derived cell lines. In this work, we assayed MGMT activity in 152 adult gliomas to establish correlates with patient and tumor characteristics. We also assayed MGMT in histologically normal brain adjacent to 87 tumors to characterize...