Nuclear medicine imaging is a powerful diagnostic tool for the management of patients with gastro-entero-pancreatic neuroendocrine tumors, mainly developed considering some cellular characteristics that are specific to the neuroendocrine phenotype. Hence, overexpression of specific trans membrane receptors as well as the cellular ability to take up, accumulate, and decarboxylate amine precursor...

Two different clinical trials using biological agents directed against an autocrine growth factor and a surface marker of neuroendocrine differentiation have been used for patients with relapsed small-cell lung cancer. In a phase II trial, an antibody (2A11) directed against the autocrine growth factor gastrin-releasing peptide has been used to treat patients with relapsed small-cell lung cance...

abstract primary neuroendocrine carcinoma of the breast is a very rare malignant tumor. there are not many cases reported in the english literature since it was first documented in 1983. reports on the imaging features, in particular the ultrasonographic features of this rare tumor are scarce. herein, we report a case of aggressive primary infiltrating neuroendocrine carcinoma of the breast, ma...

neuroendocrine tumors are most often located in the intestine and lungs but they can arise from other areas of the body. limited data is available on epidemiology and clinical patterns of neuroendocrine tumors in iran. we analyzed medical records of 34 patients from 2 cancer centers (emam khomeini hospital and omid charity cancer center) in west azarbaijan province of iran with neuroendocrine t...

The system of classification and terminology neuroendocrine neoplasms (NENs), updated in 2017 by AJCC 2019 WHO, is now recommended for general use. This article a review this with respect to NENs the digestive tract. Within new system, two categories were introdu­ced, differing morphology, clinical course treatment, as based on differentiation histological maturity grading (G). Among tract, wel...

Neuroendocrine carcinomas are rare tumors. In the head and neck region they are most common in the larynx, where they represent 0.5-1% of epithelial cancers. Diagnosis requires the recognition of the typical neuroendocrine architecture and morphology and the immunohistochemical confirmation of neuroendocrine differentiation. In the 1991 WHO classification laryngeal neuroendocrine carcinomas hav...

The role of cells of the diffuse neuroendocrine system in development and maintenance of individual organs and tissues remains poorly understood. Here we identify a regulatory region sufficient for accurate in vivo expression of synaptophysin (SYP), a common marker of neuroendocrine differentiation, and report generation of Tg(Syp-EGFP(loxP)-DTA)147(Ayn) (SypELDTA) mice suitable for flexible or...