نتایج جستجو برای: neurodevelopmental treatment

تعداد نتایج: 1403971  

Journal: :International Journal of Current Pharmaceutical Research 2023

Objective: This manuscript explores the neurodevelopmental context of early intervention for Autism Spectrum Disorder (ASD) and discusses optimal timing initiating intervention, primary approaches, predictors treatment outcomes. It also provides an overview various therapies commonly used autism. The Early Start Denver Model is highlighted as evidence-based approach.
 Methods: comparative ...

Journal: :JAMA 2014
Daniel K Benjamin Mark L Hudak Shahnaz Duara David A Randolph Margarita Bidegain Gratias T Mundakel Girija Natarajan David J Burchfield Robert D White Karen E Shattuck Natalie Neu Catherine M Bendel M Roger Kim Neil N Finer Dan L Stewart Antonio C Arrieta Kelly C Wade David A Kaufman Paolo Manzoni Kristi O Prather Daniela Testoni Katherine Y Berezny P Brian Smith

IMPORTANCE Invasive candidiasis in premature infants causes death and neurodevelopmental impairment. Fluconazole prophylaxis reduces candidiasis, but its effect on mortality and the safety of fluconazole are unknown. OBJECTIVE To evaluate the efficacy and safety of fluconazole in preventing death or invasive candidiasis in extremely low-birth-weight infants. DESIGN, SETTING, AND PATIENTS Th...

Journal: :Cold Spring Harbor perspectives in biology 2016
Jenny Hsieh Xinyu Zhao

The cellular basis of adult neurogenesis is neural stem cells residing in restricted areas of the adult brain. These cells self-renew and are multipotent. The maintenance of "stemness" and commitment to differentiation are tightly controlled by intricate molecular networks. Epigenetic mechanisms, including chromatin remodeling, DNA methylation, and noncoding RNAs (ncRNAs), have profound regulat...

Journal: :The Journal of pharmacology and experimental therapeutics 2017
Amanda Crider Anilkumar Pillai

Estrogens, the primary female sex hormones, were originally characterized through their important role in sexual maturation and reproduction. However, recent studies have shown that estrogens play critical roles in a number of brain functions, including cognition, learning and memory, neurodevelopment, and adult neuroplasticity. A number of studies from both clinical as well as preclinical rese...

2011
Claire D. Coles

Fetal alcohol syndrome and fetal alcohol spectrum disorders are underdiagnosed in general treatment settings. Among the factors involved in identifying the effects of prenatal alcohol exposure are (1) the evidence for prenatal alcohol exposure; (2) the effects of the postnatal, caregiving environment; (3) comorbidities; and (4) differential diagnosis, which includes identifying the neurodevelop...

Journal: :Cell 2013
Elaine Y. Hsiao Sara W. McBride Sophia Hsien Gil Sharon Embriette R. Hyde Tyler McCue Julian A. Codelli Janet Chow Sarah E. Reisman Joseph F. Petrosino Paul H. Patterson Sarkis K. Mazmanian

Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of gastrointestinal (GI) abnormalities. We demonstrate GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD. Oral treatment of MIA offspring wit...

Journal: :Annals of the New York Academy of Sciences 2011
Yigal Dror Jean Donadieu Jutta Koglmeier John Dodge Sanna Toiviainen-Salo Outi Makitie Elizabeth Kerr Cornelia Zeidler Akiko Shimamura Neil Shah Marco Cipolli Taco Kuijpers Peter Durie Johanna Rommens Liesbeth Siderius Johnson M Liu

Shwachman-Diamond syndrome (SDS) is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency and bone marrow failure, often associated with neurodevelopmental and skeletal abnormalities. Mutations in the SBDS gene have been shown to cause SDS. The purpose of this document is to provide draft guidelines for diagnosis, evaluation of organ and system abnormalities, and tr...

Journal: :Autism research : official journal of the International Society for Autism Research 2016
Lindsay M Oberman Peter G Enticott Manuel F Casanova Alexander Rotenberg Alvaro Pascual-Leone James T McCracken

Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental syndrome characterized by impairments in social communication, by the presence of restricted and repetitive behaviors, interests and activities, and by abnormalities in sensory reactivity. Transcranial magnetic stimulation (TMS) is a promising, emerging tool for the study and potential treatment of ASD. Recent s...

2014
Gonzalo Flores Marco Atzori

Schizophrenia and psychosis are psychiatric condition whose neural mechanisms are yet incompletely known, and for which pharmacological treatment is too often ineffective in a growing clinical cohort. Recently, dendritic morphological changes in arborization and dendritic spine density in limbic regions has been reported in postmortem tissue from schizophrenic patients and in animal models of s...

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