نتایج جستجو برای: nerve growth factor ngf

تعداد نتایج: 1598675  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1983
P J Seeley C H Keith M L Shelanski L A Greene

Exogenous proteins have been introduced into naive and nerve growth factor (NGF)-primed pheochromocytoma cells by pressure microinjection. Microinjection of cells did affect NGF-induced neurite outgrowth by these cells over periods of up to 3 days. Injected NGF failed to elicit neurite outgrowth or regeneration in the absence of extracellular NGF and failed to enhance it in its presence. Inject...

Journal: :Vision Research 2009
Valentina Sposato Vincenzo Parisi Luigi Manni Maria Teresa Antonucci Veronica Di Fausto Federica Sornelli Luigi Aloe

We investigated the effect of glaucoma (GL) on nerve growth factor (NGF) presence in two brain visual areas. Rats with elevated intraocular pressure (EIOP), induced by hypertonic saline injection in the episcleral vein, were treated with eye topical application of saline or NGF. Rats were subsequently sacrificed, and brain tissues were used for immunohistochemical, biochemical, and molecular an...

Journal: :Journal of embryology and experimental morphology 1974
D V Banthorpe F L Pearce C A Vernon

A quantitative study has been made of the effects of nerve growth factor (NGF), isolated from the venom of Vipera russelli, on the growth of dispersed cells from the sensory ganglia of the embryonic chick. The main effects were to increase the viability of the sensory neurons in culture and to promote the regeneration of nerve fibres. In the presence of NGF a higher proportion of neurons produc...

Journal: :Journal of biomaterials science. Polymer edition 2003
Terri Adams Kapur Molly S Shoichet

In order to promote regeneration after spinal cord injury, growth factors have been applied in vivo to rescue ailing neurons and provide a path finding signal for regenerating neurites. We previously demonstrated that soluble growth factor concentration gradients can guide axons over long distances, but this model is inherently limited to in vitro applications. To translate the use of growth fa...

2017
Xiushuai Shang Zhaofei Wang Hairong Tao

Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and pathogenic factors (interleukin-1β, transforming growth factor-β1, mechanical loading, and adipokines) involved in OA development. Since NGF blocking is an eff...

Journal: :Molecular medicine reports 2013
Jun-Feng Li Jian-Chang Shu Shao-Hui Tang Yan-Mei Deng Mei-Ya Fu Xia Lv

Nerve growth factor (NGF) regulates the proliferation, differentiation and survival of cells and is also involved in the wound healing and tissue remodeling processes. The biological effects of NGF are dependent upon receptor signal-mediating functions, which differ between cells. This study attempted to investigate the hepatoprotective effect and possible mechanism of β-NGF on D-galactosamine ...

2015
Xianjin Ke Qian Li Li Xu Ying Zhang Dongmei Li Jianhua Ma Xiaoming Mao

Transplantation of bone marrow mesenchymal stem cells (BMSCs) has been developed as a new method of treating diseases of the peripheral nervous system. While netrin-1 is a critical molecule for axonal path finding and nerve growth, it may also affect vascular network formation. Here, we investigated the effect of transplanting BMSCs that produce netrin-1 in a rat model of sciatic nerve crush in...

Journal: :The Journal of Cell Biology 1985
S R Heidemann H C Joshi A Schechter J R Fletcher M Bothwell

The outgrowth of neurites from rat PC12 cells stimulated by combined treatment of nerve growth factor (NGF) with cAMP is significantly more rapid and extensive than the outgrowth induced by either factor alone. We have compared the responses of PC12 cells under three different growth conditions, NGF alone, cAMP alone, and combined treatment, with respect to surface morphology, rapidity of neuri...

Journal: :Iranian journal of allergy, asthma, and immunology 2006
Azita Parvaneh Tafreshi

Experimental allergic encephalomyelitis (EAE), a demyelinating disease induced in the animals parallels multiple sclerosis in human in several aspects, provides a useful model to investigate multiple sclerosis. In this study, we have therefore used this model to study functions of nerve growth factor (NGF) in EAE. NGF with considerable effects on neuron survival, proliferation and differentiati...

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