UV-induced photoproducts (cyclobutane pyrimidine dimers, CPDs) in DNA are removed by nucleotide excision repair (NER), and the presence of transcription factors on DNA can restrict the accessibility of NER enzymes. We have investigatigated the modulation of NER in a gene promoter using the Xenopus transcription factor IIIA (TFIIIA)-5S rDNA complex and Xenopus oocyte nuclear extracts. TFIIIA alt...

Most trichothiodystrophy (TTD) patients present mutations in the xeroderma pigmentosum D (XPD) gene, coding for a subunit of the transcription/repair factor IIH (TFIIH) complex involved in nucleotide excision repair (NER) and transcription. After UV irradiation, most TTD/XPD patients are more severely affected in the NER of cyclobutane pyrimidine dimers (CPD) than of 6-4-photoproducts (6-4PP). ...

Faithful repair of DNA lesions is a crucial task that dividing cells must actively perform to maintain genome integrity. Strikingly, nucleotide excision repair (NER), the most versatile DNA repair system, is specifically down-regulated in terminally differentiated cells. This prompted us to examine whether NER attenuation might be a common feature of all G₀-arrested cells, and in particular of ...

Named entity recognition (NER) for identifying proper nouns in unstructured text is one of the most important and fundamental tasks natural language processing. However, despite widespread use NER models, they still require a large-scale labeled data set, which incurs heavy burden due to manual annotation. Domain adaptation promising solutions this problem, where rich from relevant source domai...

A majority of research interests in irregular (e.g., nested or discontinuous) named entity recognition (NER) have been paid on entities, while discontinuous entities received limited attention. Existing work for NER, however, either suffers from decoding ambiguity predicting using token-level local features. In this work, we present an innovative model NER based pointer networks, where the simu...

UNLABELLED Bisphosphonates (BPs) are pharmacological compounds widely used in the treatment of a variety of bone-related diseases, particularly where the bone-turnover is skewed in favour of osteolysis. The mechanisms by which BPs reduce bone-resorption directly acting on osteoclasts (OCs) are now largely clarified even at molecular level. The researches concerning the BPs effects on osteoblast...

Almost 70-80% of the patients with Multiple Myeloma (MM) in advancer phase, of the disease show osteolytic lesions and/or pathologic fractures, with or without secondary osteoporosis. An accelerated osteoclast-mediated bone absorption is believed to be the main cause of bone damage in MM. Osteoclast can be activated by a variety of microenvironmental factors. Bisphosphonates (BF) induce the apo...

Named entity recognition (NER) is the process of recognizing and classifying important information (entities) in text. Proper nouns, such as a person’s name, an organization’s or location’s are examples entities. The NER one modules applications like human resources, customer support, search engines, content classification, academia. In this work, we consider for low-resource Indian languages H...