The occurrence of hypercholesteremia in the nephrotic state is a long recognized phenomenon (1), but its mechanism remains to be determined. Apparently the hypercholesteremia cannot be ascribed to a primary "lipoid degeneration" of the kidney (2). Recently, studies from this laboratory (3-6) have indicated that there is a marked derangement of cholate metabolism in certain clinical and experime...

Fluid resuscitation is widely used, and many patients are therefore exposed to plasma volume expanders. Among these, colloids, particularly hydroxyethyl starches, have been shown in recent experiments and clinical studies to induce acute kidney injury. The mechanisms of colloid-induced acute kidney injury remain incompletely elucidated. The risks associated with colloid osmotic pressure elevati...

1. We have not observed gross increases in plasma volume in glomerulonephritis, nephrosis, or nephrosclerosis, even when the concentration of plasma proteins was much below normal. Our results indicate the probability that "hydremic plethora" does not occur. 2. The low protein concentration frequently observed in the plasma in nephritis is not due to increased plasma volume but to a decrease of...

An isolate of Fusarium verticillioides (MRC826) that induced experimental leukoencephalomalacia, also caused acute toxicity when fed to pigs and administered per rumen fistula to sheep. Pigs developed severe pulmonary oedema while sheep manifested severe nephrosis and hepatosis. A less toxic isolate (F. verticillioides MRC602), fed to baboons, resulted in acute congestive heart failure or hepat...

was a clear association with malaria, and that all these four cases responded well to treatment with quinine, whereas the other two patients were discharged with evidence of permanently damaged kidneys. Another report of his observations was published in 1942. His main evidence of the malarial origin of the subacute glomerular nephrosis which he described is the response to quinine, and thus he...

Enteric hyperoxaluria, a complication of jejuno-ileal bypass, is associated with renal failure owing to oxalate nephrosis or tubulo-interstitial nephritis. A 54 year old woman developed renal failure 17 months after jejuno-ileal bypass for morbid obesity. Renal biopsy showed widespread acute on chronic damage to the tubulo-interstitial compartment with extensive deposition of oxalate crystals. ...