Patients with chronic kidney disease (CKD) have been reported to benefit from different types of exercises. It has also been shown that the ACE inhibitor lisinopril, and the natural product curcumin are also beneficial in different models of CKD in rats. We assessed the influence of moderate swimming exercise (SE) on rats with adenine-induced CKD, and tested the possible effects of lisinopril a...

This study assessed the protective effect of Zizphus jujube (ZJ) extract on 5‑FU‑induced alterations in renal function markers and kidney morphology Dawley rats. Twenty-four rats were divided randomly into four groups administrated orally with 0.9% normal saline as control group, 5-FU (40 mg/kg daily for 5 days), ZJ (500 mg/ kg 5-FU+ (for 6 days). further biochemical experiments carried out blo...

This article examines the evidence justifying the use of angiotensin-converting enzyme (ACE) inhibitors as first-line antihypertensive drugs. ACE inhibitors are as effective as traditional antihypertensive agents and, in addition, exert their blood-pressure-lowering effect with near optimal hemodynamic alterations. These drugs have a good tolerance and safety profile although they induce cough ...

Tubulointerstitial hypoxia and peritubular capillary rarefaction are typical features of chronic progressive renal disease. In response to low oxygen supply, hypoxia-inducible factors (HIFs) are activated but until now, it is unclear if this increased expression leads to a stabilization of the disease process and thus is nephroprotective or contributes to interstitial fibrosis and/or tubular at...

OBJECTIVES This study was conducted to quantitatively evaluate the recovery effects of methanolic fraction Angel's wings on gentamicin (GM)-induced nephrotoxicity. MATERIAL AND METHODS Renal injury was achieved by injecting 100 mg/kg, intraperitoneally of GM in normal saline. Extract were administrated intraperitoneally at doses 200 and 400 mg/kg. Blood samples were examined for serum creatin...

the literature about nephrotoxicity of platinum derivatives, which are commonly used in paediatric oncology, such as cisplatin and carboplatin. It shows the incidence, pathomechanisms, risk factors, type and clinical features of the disorders. It presents differences in nephrotoxic effects of particular drugs, and describes possibilities of early detection and monitoring of clinical course and ...

Schisandrin B (Sch B) is one of the active dibenzocyclooctadiene lignans found in the Schisandrae Fructus. Experimental studies have shown that Sch B possesses various pharmacological properties, including anti-cancer, neuroprotective and nephroprotective activities. However, no detailed information on its biotransformation was reported in the literature. Here, we investigated the in vitro and ...

Rheum emodi or Himalayan rhubarb is a perennial herb belongs to family Polygonaceae. It has been used in various traditional systems as laxative, tonic, diuretic and to treat fever, cough, indigestion, menstrual disorder since antiquity. This paper consists of literature of Rheum emodi regarding its ethnobotany, folkloric uses, chemical properties and pharmacological studies. The material was c...