The investigations upon which this paper is based were undertaken primi-arily to exurnine the practical value of the so-called " renal efficiency tests " in children. Cases of kidney disease admitted to one of the medical wards of the Royal Liverpool Children's Hospital were systematically examined, and the results have been arfalysed. This has neceSsitated a genieral survey of kiidney dise'ase...

The ultimate prognosis of acute nephritis in children has always been a subject of interest to the paediatrician. The relative frequency of acute nephritis in childhood and the fact that many cases of renal failure in adult life cannot be explained, have led to repeated attempts to correlate the childhood illness with the adult renal failure. Until recent years and with traditional methods of e...

Acute interstitial nephritis (AIN) represents a significant cause of acute renal failure in hospital practice. An increasing number of drugs are known to cause AIN. Due to the lack of prospective, randomized clinical trials, the most effective management is still uncertain, especially the role of steroids in the resolution of interstitial nephritis remains to be further defined. We report on a ...

The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality. The pathogenesis of lupus nephritis is complex, involving innate and adaptive cellular and humoral immune responses. Autoantibodies in particular have been shown to be critical in the initiation and progression of renal injury, via interactions with both Fc-receptors a...

BACKGROUND Acute tubular necrosis and pigment induced kidney injury are well described consequences of cocaine abuse. However, acute interstitial nephritis associated with cocaine use has been previously reported in only three patients. CASE PRESENTATION We present the case of a 49-year-old man who developed acute kidney injury from biopsy-proven interstitial nephritis after nasal insufflatio...

BACKGROUND The capacity for herpesvirus to cause disease in cetaceans is unclear and may be varied depending on the different conditions of individuals and between different species. Kidney pathology and intralesional virus-associated infection have been rarely reported in cetaceans. RESULT On April 2004, an old adult male Blainville's beaked whale (Mesoplodon densirostris) 420 cm long with a...

BACKGROUND In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE). METHODS C4d levels were determined by enzyme-linked immunosorbent assay in plasma samples of patients with established SLE using a novel approach based on detection of a short linear cleavage neoepitope. Cross-sectional association...

BACKGROUND In 2006, it was reported that Focal and Segmental Glomerulosclerosis (FSGS), Minimal Change Disease (MCD) and Membranous Glomerulonephritis (MGN) were the commonest primary glomerular diseases identified from percutaneous kidney biopsies done in Jamaica for that year (n = 76). The sample size was thought to be small and might have affected the reported findings. So a three-year revie...

The physiological study of experimental nephritis caused by poisons of bacterial origin demonstrates that the poisons may produce types of nephritis in which either vascular or tubular changes predominate. Diphtheria toxin produces a nephritis which in its late stage is of the vascular type, but in its early stage is distinctly tubular. Tuberculin and mallein uniformly cause lesions of the tubu...

Background. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a common finding of renal involvement which is related to high incidence of mortality and morbidity. IL-6 is produced by leukocytes and intrinsic kidney cells that affects inflammation, increases mesangial cell proliferation, and also contributes to autoimmunity. Objective. To detect the serum level as well as ...