Antagonism of atracurium-induced neuromuscular blockade by neostigmine or edrophonium has been studied using the tetanic (50 Hz) and train-of-four (2 Hz) or single twitch responses of the adductor pollicis muscle in 22 anaesthetized patients. A further nine patients not given an anticholinesterase acted as a control group. In two groups (six patients for each anticholinesterase) in whom antagon...

Is it always necessary to antagonize residual neuromuscular block? Do children differ from adults? Use of an anticholinesterase at the end of surgery, to antagonize residual neuromuscular block induced by a non-depolarizing drug, is commonplace; it is easy to forget that such drugs were not always given routinely. When the clinical use of " Intocostrin " (a biologically standardized extract of ...

Editor’s key points † The influence of electromyographic (EMG) activity neuromuscular block (NMB) on bispectral index (BIS) is controversial. † BIS was measured before and after reversal of NMB with sugammadex or neostigmine. † BIS increased after both agents only in patients with EMG activity. † This effect should be taken into account when using BIS. Background. Sugammadex is a modified g-cyc...

THIS issue of the Journal contains a very exciting clinical report that describes the clinical efficacy of epidural sufentanil and neostigmine in laboring women. The authors examined the analgesic effects of different combinations of the two drugs without local anesthetic during the first stage of oxytocin-augmented labor. They found that a mixture of 10 g of sufentanil with 500 g of neostigmin...

THIS issue of the Journal contains a very exciting clinical report that describes the clinical efficacy of epidural sufentanil and neostigmine in laboring women. The authors examined the analgesic effects of different combinations of the two drugs without local anesthetic during the first stage of oxytocin-augmented labor. They found that a mixture of 10 g of sufentanil with 500 g of neostigmin...

Many drugs used in anaesthesia have some potential fatal consequences; for example complete heart block and Q-Tc interval prolongation. Since the parasympathetic system in children is not fully developed, electrical transmission of the heart is not stable. Neostigmine is used in order to reverse neuromuscular block but it may also lead to prolongation of Q-Tc interval. We present a case of an 1...

Prolonged neuromuscular blockade from succinylcholine after neostigmine administration has been reported in patients with frank renal failure. We present a case of prolonged neuromuscular blockade from succinylcholine administration, given 2 hours after neostigmine reversal of neuromuscular blockade in a patient with chronic renal insufficiency. This case shows that patients with chronic renal ...

Alzheimer’s disease (AD) is a neurological episode associated with the senescence process characterized by neuronal cell death in brain regions and loss of cognition. The study investigate neuroprotective potentials Moringa oleifera leaf extract Neostigmine rat model induced Aluminium chloride (AlCl3). A total number 20 rats weighing 180-240 kg were used for this they grouped into 5 4 each grou...