Iatrogenic hypoglycaemia is a well-known complication of insulin therapy in patients with diabetes mellitus and a limiting factor for glycaemic control. In a setting of endogenous insulin deficiency (type 1 and advanced type 2 diabetes), one episode of hypoglycaemia reduces both counterregulatory hormone responses to and subjective awareness of subsequent hypoglycaemia, thus impairing physiolog...

Fear of hypoglycaemia is a powerful emotion among patients treated with insulin, and hypoglycaemia remains the major factor limiting attempts to achieve and sustain normoglycaemia with intensive insulin therapy. The Diabetes Control and Complications Trial (DCCT) reported a threefold greater risk of severe hypoglycaemia in those randomised to intensive insulin therapy1,2, with most of the episo...

A 7-year-old castrated male German shepherd dog was presented with a 10-day history of intermittent lethargy, weakness and episodic seizures. Laboratory findings after admission revealed hypoglycaemia and hyperinsulinaemia. Provisional diagnosis of insulinoma was made based on the presence of concurrent hypoglycaemia and elevated insulin level. In exploratory laparotomy a small nodular mass was...

Hypoglycaemia occurring in association with certain extrapancreatic tumours, mesodermal in type and mostly malignant, has become a well-established entity of organic hypoglycaemia. Conn and Seltzer (1955), in a review of spontaneous hypoglycaemia, added this group to the well-known causes of organic hypoglycaemia, namely, pancreatic, hepatic, anterior pituitary, adrenocortical and central nervo...

Several factors can influence the ability to drive by patients with diabetes mellitus. The most important factor would be hypoglycaemia. It seems logical that hypoglycaemia unawareness would be an important risk factor for accidents. However, in everyday practice, hypoglycaemia-related accidents are rare. Moreover, it seems that only a small subset of people with diabetes is responsible for the...

Adult spontaneous hypoglycaemia is not a diagnosis per se but a manifestation of a disease. Although rare, it is important to identify spontaneous hypoglycaemia and its causes because treatment may be preventative or curative. Hypoglycaemia can occur as an epiphenomenon in many serious diseases. It is sufficient to recognise the disease's association with hypoglycaemia and then take appropriate...

BACKGROUND AND OBJECTIVE Elderly patients with diabetes are more vulnerable to the occurrence and effects of hypoglycaemia; therefore, treatments with low risk of hypoglycaemia are preferred in this population. This study aimed to compare hypoglycaemia rates between insulin degludec (IDeg) and insulin glargine (IGlar) in elderly patients. METHODS Hypoglycaemia data from patients ≥65 years of ...

Hypoglycaemia is the most frequent and serious complication of insulin therapy and is three times more common in those who are intensively treated. Impaired awareness of hypoglycaemia is a major limitation to achieving tight diabetes. Asymptomatic biochemical hypoglycaemia occurs more frequently during routine blood glucose monitoring and this should alert the clinician that the individual is d...

Adult spontaneous hypoglycaemia is not a diagnosis per se but a manifestation of a disease. Although rare, it is important to identify spontaneous hypoglycaemia and its causes because treatment may be preventative or curative. Hypoglycaemia can occur as an epiphenomenon in many serious diseases. It is sufficient to recognise the disease’s association with hypoglycaemia and then take appropriate...

A study was designed to investigate whether asthma, when carefully managed, is associated with an increased risk of complications in connection with pregnancy. One hundred and eighty one asthmatic women were monitored during 198 pregnancies. Antiasthmatic treatment consisted of inhaled beta 2 adrenergic drugs, beclomethasone, sodium cromoglycate, oral theophylline, and systemic corticosteroids ...