Background: Indirect hyperbilirubinemia is one of the most common causes hospitalization in neonatal period and its potential association with brain damage well established. This study was conducted to determine neurodevelopmental outcome children who had severe indirect received intensive phototherapy or without double volume exchange transfusion for management. Material & methods: descrip...

Background: Many cases of severe neonatal hyperbilirubinemia never have the underlying cause of the jaundice clearly identified. Thus they are said to have ‘idiopathic’ severe neonatal jaundice. However, finding the exact cause, if it is a genetic condition, can enable informed anticipatory guidance regarding future episodes of hemolysis, anemia, or bilirubin cholelithiasis. Objective: ‘Next ge...

Background: Many cases of severe neonatal hyperbilirubinemia never have the underlying cause of the jaundice clearly identified. Thus they are said to have ‘idiopathic’ severe neonatal jaundice. However, finding the exact cause, if it is a genetic condition, can enable informed anticipatory guidance regarding future episodes of hemolysis, anemia, or bilirubin cholelithiasis. Objective: ‘Next ge...

Phototherapy: A simple and safe treatment for Neonatal Jaundice. Jaundice is a common finding in premature and full term newborns. Phototherapy has been widely used in the management of Neonatal unconjugated Hyperbilirubinemia for over five decades. Phototherapy devices include Fluorescent, Halogen, Fiberoptic or Light-Emitting Diode light sources. Safety issues and possible complications of ph...

In the 1940s and the 1950s, severe neonatal hyperbilirubinemia and kernicterus were most often encountered with hemolytic disease of newborn (HDN), which occurs most often as a result of the incompatibilities of the Rh and ABO blood groups. With the advent of prenatal testing, maternal Rh°(D) immunoglobulin, phototherapy, and exchange transfusion, the incidence of severe hyperbilirubinemia dras...

Placental transfusion has been cornpared in premature and full-term infants. Blood volume measurements showed that the 5-minute transfusion was similar in full-term and premature infants (47% and 50% increase in blood volume from birth) . A larger proportion of the 5-minute transfusion occurred by 1 minute in full-term ( 76%) than in premature infants (56%). Placental transfusion, by increasing...

This content is licensed under a Creative Commons Attribution 4.0 International License. Cholestasis occurs due to reduced synthesis of bile acids or the deficient (intra or extra-hepatic) excretion of biliary components (cholesterol, phospholipids, bile salts, bilirubin and proteins) to the small intestine. Newborns, especially preterm-born children, have a predisposition to neonatal cholestas...

Background: Many cases of severe neonatal hyperbilirubinemia never have the underlying cause of the jaundice clearly identified. Thus they are said to have ‘idiopathic’ severe neonatal jaundice. However, finding the exact cause, if it is a genetic condition, can enable informed anticipatory guidance regarding future episodes of hemolysis, anemia, or bilirubin cholelithiasis. Objective: ‘Next ge...

OBJECTIVE To investigate the association between neonatal hyperbilirubinemia and autism spectrum disorders (ASD). METHODS We conducted a large case-control study nested within the cohort of singleton term infants born between 1995 and 1998 at a northern California Kaiser Permanente hospital. Case subjects (n = 338) were children with an ASD diagnosis recorded in Kaiser Permanente outpatient d...