We have developed a new antimetastatic chemotherapeutic strategy for combination with hepatic resection of human colon cancers in a high-metastasis nude mouse model. The new procedure involves i.p. administration of 5-fluorouracil (5-FU) 2 h before hepatic resection of the human colon tumors, with therapy continued postoperatively for 4 consecutive days. We termed this strategy neo-neoadjuvant ...

The standard treatment of resectable pancreatic cancer is surgery followed by adjuvant chemotherapy. Due to the complication rate of pancreatic surgery and the high rate of primary irresectability, neoadjuvant concepts are increasingly used for pancreatic cancer. Neoadjuvant therapy is better tolerated than adjuvant and might decrease the surgical complication rate from pancreatic surgery. In c...

PURPOSE Recent studies have shown promising results of neoadjuvant therapy in prostate cancer (PC). The aim of this study was to evaluate the potential of [11C]Choline PET/CT in therapy response monitoring after combined neoadjuvant docetaxel chemotherapy and complete androgen blockade in locally advanced and high risk PC patients. RESULTS In [11C]Choline PET/CT there was a significant decrea...

introduction: solar lentigines are among commonest cosmetic problems. there are many topical therapies suggested to treat these lesions including cryotherapy, chemical peeling with tri chloro acetic acid (tca) and laser therapy with q-switched lasers as well as long pulsed lasers. considering possible treatment side effects (pih, scar) with cryotherapy and peeling in iranian patients (darker sk...

Triple-negative breast cancer (TNBC) is a heterogeneous disease that can be classified into distinct molecular subtypes by gene expression profiling. Considered a difficult-to-treat cancer, a fraction of TNBC patients benefit significantly from neoadjuvant chemotherapy and have far better overall survival. Outside of BRCA1/2 mutation status, biomarkers do not exist to identify patients most lik...

Purpose: Pathologic complete response (pCR) to neoadjuvant chemotherapy reflects the cytotoxic efficacy of a drug, but patient survival is influenced by many other factors. The purpose of this studywas to assess the relationshipbetween increasedpCR rate and trial-level survival benefit in triple-negative breast cancer (TNBC). Experimental Design:We used bootstrap resampling from a neoadjuvant t...

results the mean age in breathing technique with lavender and breathing technique alone were 25.5 ± 4.3 and 26 ± 4.9, respectively .two groups were comparable in this regards (p = 0.6), but the length of active phase in interventional group was 7.85 ± 3.85 hours and in the control group it was 9.88 ± 6.65 hours. the decrease of the length of labor in the active phase was higher in the experimen...

Several types of soft tissue sarcomas have peripheral infiltrative growth characteristics called tail-like lesions. The efficacy neoadjuvant therapy for tumors with lesions has not been elucidated. From 2012 to 2019, we analyzed 36 patients sarcoma treated therapy, including chemotherapy, radiotherapy, or both. effect on the tail sign was investigated by analyzing change in during and histologi...