metastatic tumors to the heart unlike primary cardiac tumors are not rare. despite its frequency, cardiac metastasis is commonly detected only during autopsy as the symptoms of disseminated metastasis prevail over symptoms caused by cardiac metastasis and hence is overlooked most of the time. tumors more commonly found metastasizing to the heart are malignancies of lung, breast, esophagus, lymp...

nasal mucosa has an extraordinary nerve supply with unique geometry that encompasses complex physiology. among these, side-specific predilections to the respiratory and autonomic centers are the interesting issues that have been raised about the consequences of the nasal irritations. the aim of the study was an evaluation of how intranasal stimulation influences lung mechanics and determines wh...

background: superficial mucocele presents as small, clear vesicle on noninflamed mucosa. in this study, we report several vesicles on the bucal mucosa of a woman diagnosed as superficial mucocele.case presentation: a 48-year old woman presented with multiple vesicles on her labial mucosa, ventral surface of the tongue, floor of the mouth and palate. a mucosal biopsy was taken from the vesicle. ...

background there is a potential risk for malignancy in patients with diabetes mellitus. theoretically, a noninvasive method for detection of precancerous changes can be conducted on oral exfoliated cell smears. objectives in this study, the immunocytochemistry of p53 in exfoliated oral mucosal cells in patients with type 2 diabetes was investigated. patients and methods oral mucosal smears were...

We have identified genes required for competence of Neisseria meningitidis, a naturally transformable human pathogen. Although not comprehensive, our analysis identified competence-defective mutants with transposon insertions in genes not previously implicated in this process in Neisseria.

objective: the lack of adequate recognition of health importance of non-hiv reproductive health infections (rhis) in nigeria has led into this study, which was to determine clinical pathogens in non-hiv rhi in nigeria using a tertiary health facility as case study. materials and methods: a nine-year investigation was carried out between 1997 and 2005 on 4047 (n = 1626 males; n = 2421 females) p...

The three species Neisseria meningitidis, Neisseria gonorrheae, and Neisseria lactamica are often regarded as highly recombining bacteria. N. meningitidis has been considered a paradigmatic case of the "semiclonal model" or of "epidemic clonality," demonstrating occasional bouts of clonal propagation in an otherwise recombining species. In this model, occasional clonality generates linkage dise...

Long pentraxin 3 (PTX3) is a non-redundant component of the humoral arm of innate immunity. The present study was designed to investigate the interaction of PTX3 with Neisseria meningitidis. PTX3 bound acapsular meningococcus, Neisseria-derived outer membrane vesicles (OMV) and 3 selected meningococcal antigens (GNA0667, GNA1030 and GNA2091). PTX3-recognized microbial moieties are conserved str...

DNA mimicry is a direct and effective strategy by which the mimic competes with DNA for the DNA binding sites on other proteins. Until now, only about a dozen proteins have been shown to function via this strategy, including the DNA mimic protein DMP19 from Neisseria meningitides. We have shown previously that DMP19 dimer prevents the operator DNA from binding to the transcription factor NHTF. ...