نتایج جستجو برای: negative breast cancer
تعداد نتایج: 1460192 فیلتر نتایج به سال:
Breast cancer is a major concern and one of the leading causes of cancer-related death worldwide. Breast cancer, like many other types of cancer, is a complex heterogeneous disease controlled by a multitude of genetic and epigenetic alterations. The hormonal status of ER and PR, HER2/neu helps in identifying the non aggressive behavior and patients likely to achieve benefit from endocrine thera...
In this issue of the Journal, Jung et al. (1) report no overall effect of fruit and vegetable consumption on breast cancer risk among women in the large, long-term Pooling Project of Prospective Studies of Diet and Cancer (Pooling Project). When the authors considered hormone-responsive, estrogen receptor (ER)–positive patients separately from the nonhormonal, ER-negative patients under a hypot...
Introduction:The accuracy of positron emission tomography with computed tomography (PET/CT), positron emission mammography (PEM), and breast specific-gamma imaging (BSGI) in diagnosing breast cancer has never been systematically assessed, the present systematic review was aimed to address this issue. Methods:PubMed, Scopus and EMBASE were searched for st...
Genome-wide association studies (GWAS) have identified more than 90 susceptibility loci for breast cancer, but the underlying biology of those associations needs to be further elucidated. More genetic factors for breast cancer are yet to be identified but sample size constraints preclude the identification of individual genetic variants with weak effects using traditional GWAS methods. To addre...
An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.
Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ER+/PR+ and HER2+ tumors have revolutionized patient treatment and increased lifespan, an urgent need exists for identifyi...
Whereas the Her2/neu/erbB2 receptor (Her2) could be a molecular target of the receptor-positive breast cancer, the therapeutic targets of Her2-negative cancer largely remain to be established. The expression of Her2 was evaluated in 48 primary breast cancer tumors by immunohistochemistry. The identified Notch pathway was studied in genotoxin-dependent suppression of breast cancer-initiating cel...
Background & objective Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell proliferation, and lymphagiogenesis. SPHK1 is overexpressed in multiple types of cancer including...
Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ERþ/PRþ), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ERþ/PRþ and HER2þ tumors have revolutionized patient treatment and increased lifespan, an urgent need exists for identifyi...
In the current study, we sought to examine the effects of curcumin in a specific type of breast cancer called triple negative breast cancer. These cancers lack expression of the estrogen and progesterone receptors and do not over-express HER2. Current treatment for triple negative breast cancers is limited to cytotoxic chemotherapy, and upon relapse, there are not any therapies currently availa...
Received: 15 Aug, 2012 Accepted: 9 Oct, 2012 Abstract Background & Aims: Breast cancer is the most common malignant tumor in women. In our country (Iran) based on the study of the “Institute of cancer”, breast cancer accounts for 10.8% of all newly diagnosed cancers. Because of different clinical course of breast cancer in sufferers, identifying the factors that directly or indirectly pre...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید