188 P&T® • April 2009 • Vol. 34 No. 4 INTRODUCTION Hypertension is an asymptomatic condition of persistently elevated blood pressure (BP) that affects approximately 50 million Americans and one billion people worldwide. It has been associated with other diseases and events such as myo cardial infarction (MI), heart failure, stroke, and kidney disease. Although hypertension the most common prima...

Diabetes mellitus (DM) and hypertension are two common diseases that often coexist. The most common cause of death in the diabetic patient is heart disease. In the present investigation we combine Nebivolol and Nateglinide for better patient compliance. IR layer was formulated using various superdisintegrants like Crospovidone, Croscarmellose sodium, and sodium starch glycolate and SR layer was...

BACKGROUND The sympathetic nervous system has a unique role in endothelial function, and beta-receptors are a key part of sympathetic nervous system function. OBJECTIVE To elucidate the pharmacological augmentation of endotheliumderived nitric oxide synthesis. SUMMARY Beta-blockers have been commercially available since the 1960s. Stimulating beta-receptors causes dilatation whereas blockin...

Objective: The aim of this study was to investigate the potential a liquisolid system improve dissolution rate and bioavailability nebivolol hydrochloride. Methods: Solubility determined in different nonvolatile solvents finalize best vehicle having maximum solubility. compacts were prepared using Fujicalin as carrier material, Aerosil 200 coating Polyethylene glycol 400 liquid vehicle, Croscar...

A simple, selective, rapid, precise and economical reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of nebivolol and hydrochlorthiazide from pharmaceutical formulation. Phenomenex Gemini C(18) (25 cm×4.6 mm i.d., 5 μ) column with a mobile phase consisting of acetonitrile: 50mM ammonium acetate (adjusted to pH 3.5 using orthophosphoric ...

While the exploitation of the Sharpless asymmetric dihydroxylation as the source of chirality in the synthesis of acyclic molecules and saturated heterocycles has been tremendous, its synthetic utility toward chiral benzo-annulated heterocycles is relatively limited. Thus, in the search for wider applications of Sharpless asymmetric dihydroxylation-derived diols for the synthesis of benzo-annul...