Sr, Nd and Pb isotope data for basalts from spreading axes and off-axis volcanoes near the Pacific–Antarctic risecrest, from Vacquier transform to just south of Udintsev transform, reveal an isotopically heterogeneous upper mantle. The Ž . isotopic composition of the mantle is represented by three end-members: 1 the ‘depleted’ source of the bulk of Pacific Ž . Ž . normal-type mid-ocean ridge ba...

INTRODUCTION Development of evidence-based methods of paralympic classification requires research quantifying the relative strength of association between ratio-scaled measures of impairment and sports performance. To date, no such research has been conducted. The purpose of this study was to quantify the extent to which range of movement (ROM) and coordination affect running performance in run...

To investigate the roles of plasma miR-21 in the pathogenic process of Type 2 diabetes (T2D) with diabetic retinopathy (DR). T2D patients included patients without DR (NDR) group, patients with non-proliferative/background DR (BDR) group and patients with proliferative DR (PDR) group. Healthy individuals served as control group. Fasting plasma glucose (FPG), glycosylated haemoglobin (HbA1c), tr...

As a sanity test for the theoretical method employed, studies on (steady-state) charge transport through molecular devices usually confine themselves to check whether the method in question satisfies the charge conservation. Another important test of the theory's correctness is to check that the computed current does not depend on the choice of the central region (also referred to as the "exten...

BackgroundDiabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM). Diabetic causes permanent blindness in the productive age group and has multifactorial pathogenesis. MicroRNA-126 (miRNA-126) regulates expression vascular endothelial growth factor (VEGF) gene at post-transcriptional level, VEGF being an important angiogenic protein regulating inflammation DR develop...

The pathogenesis of diabetic retinopathy is still challenging, with recent evidence proving the key role inflammation in damage retinal neurovascular unit. This study aims to investigate predictive value neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR), and systemic index (SII) for (DR) its severity. We performed a retrospective on 129 T2DM patien...

In the RESEARCH DESIGN AND METHODS section of the article cited above, page 454, the sentences “We used data from the Swedish Childhood Diabetes Register (SCDR), Swedish National Diabetes Register (NDR), and the Swedish National Patient Register (NPR) to identify patients (probands) born in Sweden from 1964 onward with onset of type 1 diabetes before 18 years of age. Since 1 July 1977, the SCDR...

Diabetic retinopathy (DR), one of the major complications diabetes, can cause blindness and reduce quality life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed investigate association circulating n-3 n-6 polyunsaturated fatty acids (PUFAs) In this cross-sectional study, 190 Japanese patients type 2 diabetes were clas...

In the Gunn effect, which occurs in certain semiconductors in strong electric fields, electrons are driven out of a low-mass central valley into a heavy-mass side valley in k (momentum) space, ultimately resulting in negative differential resistance (NDR). Recently, there has been interest in the possibility of exploiting this phenomenon in heterostructured semiconductors, as a means to realize...

BACKGROUND Health-economic models of diabetes are complex since the disease is chronic, progressive and there are many diabetic complications. External validation of these models helps building trust and satisfies demands from decision makers. We evaluated the external validity of the IHE Cohort Model of Type 2 Diabetes; the impact of using alternative macrovascular risk equations; and compared...